Korean J Med.  2018 Feb;93(1):50-54. 10.3904/kjm.2018.93.1.50.

Hepatic Arterial Infusion Chemotherapy Using the Port System in Advanced Gallbladder Cancer

• Eun JR
• Kim JW
• Choi JH

• KMID: 2435035
• DOI: http://doi.org/10.3904/kjm.2018.93.1.50

Abstract

Gallbladder (GB) cancer is relatively rare and has a poor prognosis, with a median survival time of less than 3 months. It is resistant to chemotherapy. Therefore, the role of systemic chemotherapy is limited. However, administering the anticancer agent directly into the hepatic artery can result in a higher drug concentration in the cancer tissue. In this paper, we report a case of advanced GB cancer treated with hepatic arterial infusion chemotherapy (HAIC) using the port system. The patient received six cycles of HAIC with 5-fluorouracil (750 mg/m²) and cisplatin (25 mg/m²); each cycle lasted for 4 days every month. The tumor showed objective response during HAIC, and the patient survived for 15 months from the first therapy. HAIC using the port system might be a promising therapeutic modality for treating locally advanced GB cancer.

Keyword

Gallbladder cancer; Chemotherapy; Hepatic artery

MeSH Terms

Cisplatin
Drug Therapy*
Fluorouracil
Gallbladder Neoplasms*
Gallbladder*
Hepatic Artery
Humans
Prognosis
Cisplatin
Fluorouracil