J Vet Sci.  2019 Jan;20(1):98-101. 10.4142/jvs.2019.20.1.98.

Corneoconjunctival manifestations of lymphoma in three dogs

• Kang S
• Jeong M
• Seo K

• KMID: 2434785
• DOI: http://doi.org/10.4142/jvs.2019.20.1.98

Abstract

An 8-year-old Shih Tzu, a 5-year-old Maltese, and a 10-year-old Maltese presented with conjunctival hyperemia and peripheral corneal edema. Severe conjunctival thickening with varying degrees of corneal extension was observed. Cytological examination showed many large lymphocytes with malignant changes in the conjunctiva which was consistent with findings in fine-needle aspiration samples taken from regional lymph nodes. They were diagnosed as having Stage V multicentric lymphoma. When conjunctival thickening is observed in canine patients with multicentric lymphoma, conjunctival metastasis with infiltration of neoplastic lymphoid cells should be included in the differential diagnosis.

Keyword

Canine; Conjunctiva; Cornea; Multicentric lymphoma; Uvea

MeSH Terms

Animals
Biopsy, Fine-Needle
Child
Child, Preschool
Conjunctiva
Cornea
Corneal Edema
Diagnosis, Differential
Dogs*
Humans
Hyperemia
Lymph Nodes
Lymphocytes
Lymphoma*
Neoplasm Metastasis
Uvea

Figure

• 

  Fig. 1 Clinical appearance on initial presentation and the diagnostic approaches used. (A) The left eye in C1 (an 8-year-old neutered male Shih Tzu). (B) The right eye in C2 (a 5-year-old neutered male Maltese). (C) The left eye in C3 (a 10-year-old neutered male Maltese). Conjunctival thickening and hyperemia with corneal perilimbal (C1 and C2) or generalized (C3) edema and neovascularization were observed. Hypopyon (asterisk) was also seen in C2 (B). (D) The cytologic appearance of a fine-needle aspirate from conjunctiva in C1. Medium-sized to large-sized lymphocytes with malignant changes were detected. 400×. Scale bar = 100 µm. (E and F) Respective B-scan ultrasound images for C1 and C3. Thickening of the ciliary body (arrows) and echogenic masses within the vitreous body (arrowheads) with vitreous degeneration were evident.

• 

  Fig. 2 Clinical appearance on follow-up examination. (A) The left eye in C1 (an 8-year-old neutered male Shih Tzu) after one month; the perilimbal corneal involvement improved and the conjunctival thickening and hyperemia also subsided. (B and C) The left eye in C3 (a 10-year-old neutered male Maltese) after 3 and 7 weeks, respectively; the conjunctival thickening subsided and the corneal edema and neovascularization also decreased. The corneoconjunctival lesions improved over time despite persistent corneal fibrosis.

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