Ann Dermatol.  2012 May;24(2):230-232.

Erythema Multiforme after Radiotherapy with 5-fluorouracil Chemotherapy in a Rectal Cancer Patient

• Han JH
• Yun SJ
• Nam TK
• Choi YD
• Lee JB
• Kim SJ

Abstract

No abstract available.

MeSH Terms

Erythema
Erythema Multiforme
Fluorouracil
Humans
Rectal Neoplasms
Fluorouracil

Figure

• 

  Fig. 1 At the first visit, erythematous targetoid papules and plaques were distributed on the buttocks (a, b), the dorsum of the hands (c), and the ears (d).

• 

  Fig. 2 Skin biopsy showing vacuolar changes in the basal layer, and mild perivascular inflammatory cells, including many eosinophils, infiltrating in the dermis (H&E, ×100).

• 

  Fig. 3 Schematic representation of disease progression. After the third cycle of 5-FU administration, radiotherapy was added to the treatment, and EM developed after the fourth administration of 5-FU. Radiotherapy was stopped, and EM recurred following the fifth administration of 5-FU. 5-FU: 5-fluorouracil, EM: erythma multiforme.

Reference

1. Lo SK, Yip D, Leslie M, Harper P. 5-fluorouracil-induced erythema multiforme. Int J Clin Pract. 1999. 53:219–221.

2. Fleischer AB Jr, Rosenthal DI, Bernard SA, O'Keefe EJ. Skin reactions to radiotherapy--a spectrum resembling erythema multiforme: case report and review of the literature. Cutis. 1992. 49:35–39.

3. Spencer HJ. Local erythema multiforme-like drug reaction following intravenous mitomycin C and 5-fluorouracil. J Surg Oncol. 1984. 26:47–50.

4. Ahmed I, Reichenberg J, Lucas A, Shehan JM. Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature. Int J Dermatol. 2004. 43:67–73.

5. Helsby NA, Lo WY, Thompson P, Laking GR. Do 5-fluorouracil therapies alter CYP2C19 metaboliser status? Cancer Chemother Pharmacol. 2010. 66:405–407.

6. Taliarero WH, Taliarero LG, Jaroslow BN. Taliarero WH, Taliarero LG, Jaroslow BN, editors. Radiation-induced changes in the primary antibody response as related to species, antigen dosage, and radiation dose. Radiation and immune mechanisms. 1964. New York: Academic Press;31–64.

7. Tubiana M. Dubois JB, Serrou B, Rosenfeld C, editors. Does postoperative radiotherapy facilitate metastatic dissemination? Immunopharmacologic basis of radiation therapy. 1981. New York: Raven Press;399–414.

8. Rodríguez-Pazos L, Sánchez-Aguilar D, Rodríguez-Granados MT, Pereiro-Ferreirós MM, Toribio J. Erythema multiforme photoinduced by statins. Photodermatol Photoimmunol Photomed. 2010. 26:216–218.