Ann Dermatol.  2012 May;24(2):225-227.

Simultaneous Involvement of Nervous and Gastrointestinal Systems in Behcet's Disease

• Lee JY
• Park JY
• Kim EH
• Tak MJ
• Lee ES

Abstract

No abstract available.

Figure

• 

  Fig. 1 Axial brain magnetic resonance imaging revealed a hyperintense lesion in the right central area of the mesodiencephalic junction on a T2-weighted image (A: midbrain, B: upper pons) and a fluid-attenuated inversion-recovery sequence (C: midbrain, D: upper pons). These findings suggested that a small infarction had occurred (arrows).

• 

  Fig. 2 (A) Abdominal computed tomography study revealed an ulcerative lesion in the terminal ileum (arrows). (B) The specimen from ileocecal resection revealed perforating enterocolitis with multiple ulceration, lymphoid aggregates, and fibrosis, consistent with Behçet's colitis (original magnification, H&E, ×10).

Reference

1. Sakane T, Takeno M, Suzuki N, Inaba G. Behçet's disease. N Engl J Med. 1999. 341:1284–1291.

2. Bayraktar Y, Ozaslan E, Van Thiel DH. Gastrointestinal manifestations of Behcet's disease. J Clin Gastroenterol. 2000. 30:144–154.

3. Lakhanpal S, Tani K, Lie JT, Katoh K, Ishigatsubo Y, Ohokubo T. Pathologic features of Behçet's syndrome: a review of Japanese autopsy registry data. Hum Pathol. 1985. 16:790–795.

4. Kim HJ, Bang D, Lee SH, Yang DS, Kim DH, Lee KH, et al. Behçet's syndrome in Korea: a look at the clinical picture. Yonsei Med J. 1988. 29:72–78.

5. Bang D, Lee JH, Lee ES, Lee S, Choi JS, Kim YK, et al. Epidemiologic and clinical survey of Behcet's disease in Korea: the first multicenter study. J Korean Med Sci. 2001. 16:615–618.

6. Al-Araji A, Kidd DP. Neuro-Behçet's disease: epidemiology, clinical characteristics, and management. Lancet Neurol. 2009. 8:192–204.

7. Ohira H, Tsutsumi A, Yasuda S, Horita T, Takeuchi R, Kasahara H, et al. Severe neuro-Behçet with perforation of the intestine. Nihon Naika Gakkai Zasshi. 2000. 89:1435–1437.

8. Ideguchi H, Suda A, Takeno M, Kirino Y, Ihata A, Ueda A, et al. Neurological manifestations of Behçet's disease in Japan: a study of 54 patients. J Neurol. 2010. 257:1012–1020.

9. Ideguchi H, Suda A, Takeno M, Ueda A, Ohno S, Ishigatsubo Y. Behçet disease: evolution of clinical manifestations. Medicine (Baltimore). 2011. 90:125–132.

10. Alpsoy E, Donmez L, Onder M, Gunasti S, Usta A, Karincaoglu Y, et al. Clinical features and natural course of Behçet's disease in 661 cases: a multicentre study. Br J Dermatol. 2007. 157:901–906.

11. Kim MC, Shin SJ, Lim SG, Lee KR, Woo H, Choi SJ, et al. Clinical course of intestinal Behcet's disease according to the characteristics of ulcer in colonoscopy. Intest Res. 2010. 8:40–47.

12. Ikezoe K, Yamashita Y, Sakai Y, Yamamoto I. Neuro-Behçet's disease with unilateral multiple brain lesions during the active phase of entero-Behçet's disease: a case report. Shinkeinaika. 1998. 49:537–540.

13. Lee YJ, Kang SW, Baek HJ, Choi HJ, Bae YD, Kang EH, et al. Association between matrix metalloproteinase 9 promoter polymorphisms and Behçet's disease. Hum Immunol. 2010. 71:717–722.