Korean J Dermatol.  2019 Jan;57(1):20-23.

Two Cases of Lupus Miliaris Disseminatus Faciei Treated with Oral Mini-pulse Steroid Therapy

• Na CH
• Lee YS
• Choi H
• Shin BS
• Kim MS

Abstract

Lupus miliaris disseminatus faciei (LMDF) is a rare granulomatous skin disease mainly affecting the central area of the face. A variety of treatments are reportedly of some benefit; however, controlled studies to establish the best treatment are lacking. Here, we report the cases of a 33-year-old man who presented with multiple, various-sized, erythematous maculopapules on the face and a 19-year-old man who presented multiple, reddish papuloplaques distributed on the face. Histopathological examinations of the two cases revealed large clear-boundary epithelioid cell granulomas with central necrosis surrounded by lymphocytic infiltration. Based on the clinical and histological findings, diagnoses of LMDF were made. As oral tetracycline and antimalarials were not fully effective in our cases, oral mini-pulse steroid therapy (dexamethasone, 5 mg bid for 2 days per week) was initiated. After several months, the eruption significantly improved, and most lesions were resolved. Here, we report two cases of LMDF successfully treated with oral mini-pulse steroid therapy.

Keyword

Lupus miliaris disseminatus faciei; Oral mini-pulse steroid therapy

MeSH Terms

Adult
Antimalarials
Diagnosis
Epithelioid Cells
Granuloma
Humans
Necrosis
Skin Diseases
Tetracycline
Young Adult
Antimalarials
Tetracycline