Chonnam Med J.  2016 Sep;52(3):159-172. 10.4068/cmj.2016.52.3.159.

Second Generation Antipsychotics in the Treatment of Major Depressive Disorder: An Update

• Wang SM
• Han C
• Lee SJ
• Jun TY
• Patkar AA
• Masand PS
• Pae CU

• KMID: 2432266
• DOI: http://doi.org/10.4068/cmj.2016.52.3.159

Abstract

Less than one third of patients who suffer from major depressive disorder (MDD) report remission following antidepressant treatments requiring more diverse treatment approaches. Augmentation of second generation antipsychotics (SGAs) has been increasingly recognized as an important treatment option. The authors have previously provided a comprehensive review of SGAs for the treatment of MDD in 2013. Since then, numerous additional clinical trials have been conducted to investigate diverse issues regarding the utility of SGAs in MDD. Moreover, a new SGA, brexpiprazole, was recently approved by the Food and Drug Administration in July 2015 for the treatment of MDD as an augmentation agent to antidepressants. Thus, the aim of this study was to provide a concise update of all the available SGAs for the treatment of MDD, in particular on the additional clinical trials which have been published since 2013.

Keyword

Antidepressive Agents; Depressive Disorder; Clinical Trial; Antipsychotic Agents; Depressive Disorder, Treatment-Resistant

MeSH Terms

Antidepressive Agents
Antipsychotic Agents*
Depressive Disorder
Depressive Disorder, Major*
Depressive Disorder, Treatment-Resistant
Humans
United States Food and Drug Administration
Antidepressive Agents
Antipsychotic Agents

Figure

• 

  FIG. 1 Evolution of antidepressant. MAOI: monoamine oxidase inhibitors, NDRI: norepinephrine-dopamine reuptake inhibitor (NDRI), Rc: receptors, RI: reuptake inhibitor, SNRI: norepinephrine reuptake inhibitor, SSRI: selective serotonin reuptake inhibitors, TCA: tricyclic antidepressants.

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