Korean Circ J.  2019 Jan;49(1):115-117. 10.4070/kcj.2018.0305.

Clinical and Histological Response to Immunosuppressive Therapy in Giant Cell Myocarditis

• Choi YJ
• Cho HJ

• KMID: 2430756
• DOI: http://doi.org/10.4070/kcj.2018.0305

Abstract

No abstract available.

MeSH Terms

Giant Cells*
Myocarditis*

Figure

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  Figure 1 Histological findings on endomyocardial biopsy. (A) Diffuse geographic myocarditis with severe necrotic change and inflammatory infiltrate (H&E, ×100). (B) Numerous multinucleated giant cells in nongranulomatous background. (C) Collection of inflammatory cells including variable numbers of giant cells (arrows), histiocyte, T-lymphocyte, and eosinophils. (D) The area with necrotic change and severe inflammation showed negative of desmin. (E) Histiocyte infiltration in myocardium (CD68 staining). (F) T-lymphocyte infiltrate in myocardium (CD3, Pan-T cell marker staining).H&E = hematoxylin and eosin.

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  Figure 2 Follow-up endomyocardial biopsy. (A) On 12th day from starting immunosuppressive therapy, myocardial biopsy revealed a marked reduction of the inflammatory infiltrate and the absence of giant cells. The fibrotic and fatty change are seen in the area, where there was necrotic change before treatment (H&E, ×200). (B) On 46th day, massive granulation tissue and fatty change without active myocardial damage was observed (H&E, ×400).H&E = hematoxylin and eosin.

Reference

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