Kosin Med J.  2018 Dec;33(2):141-149. 10.7180/kmj.2018.33.2.141.

What to do with troublesome hot flush?

• Chae SH
• Lee C
• Kim HY
• Lee JY

• KMID: 2430729
• DOI: http://doi.org/10.7180/kmj.2018.33.2.141

Abstract

Hot flush (hot flush or facial flush) is the most frequent symptom experienced by women of peri-menopausal age. It may appear on women or even men after surgery or chemotherapy. Hot flush is one of the biggest reason for women to undergo hormone replacement therapy (HRT). It also crucially affects various aspects of life quality such as occupation, social life, daily routine and health awareness. The most effective and fundamental remedy for hot flush is HRT. However, a few women is not responsive to HRT and investigation to elucidate other causes of hot flush is warranted, especially in elderly. The contraindications such as breast cancer mandates other modality of treatment. Variety of treatment for hot flush other than HRT will be discussed herein.

Keyword

Hot flush; Treatment

MeSH Terms

Aged
Breast Neoplasms
Drug Therapy
Female
Hormone Replacement Therapy
Humans
Male
Occupations
Quality of Life

Reference

1. Lee JH, Chung YK, Park HM, Park JS, Yumiko H, Yeoum SG. A Study on Climateric Symptoms in Korean Midlife Women. J Korean Soc Menopause. 2000; 6:141–156.

2. Gold EB, Sternfeld B, Kelsey JL, Brown C, Mouton C, Reame N, et al. Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40–55 years of age. Am J Epidemiol. 2000; 152:463–473.

3. McKinlay SM, Brambilla DJ, Posner JG. The normal menopause transition. Am J Hum Biol. 1992; 4:37–46.

4. Cagnacci A, Palma F, Romani C, Xholli A, Bellafronte M, Di Carlo C. Are climacteric complaints associated with risk factors of cardiovascular disease in peri-menopausal women? Gynecol Endocrinol. 2015; 31:359–362.

5. Lobo RA. Treatment of postmenopausal women: Base and clinical aspects. 2nd edition. Philadelphia: Lippincott Wiliams & Wikins;1999.

6. Freedman RR, Norton D, Woodward S, Cornélissen G. Core body temperature and circadian rhythm of hot flashes in menopausal women. J Clin Endocrinol Metab. 1995; 80:2354–2358.

7. Berendsen HH. The role of serotonin in hot flushes. Maturitas. 2000; 36:155–164.

8. Kronenberg F, Downey JA. Thermoregulatory physiology of menopausal hot flashes: a review. Can J Physiol Pharmacol. 1987; 65:1312–1324.

9. Stearns V, Ullmer L, López JF, Smith Y, Isaacs C, Hayes D. Hot flushes. Lancet. 2002; 360:1851–1861.

10. Krause MS, Nakajima ST. Hormonal and nonhormonal treatment of vasomotor symptoms. Obstet Gynecol Clin North Am. 2015; 42:163–179.

11. Bullock JL, Massey FM, Gambrell RD Jr. Use of medroxyprogesterone acetate to prevent menopausal symptoms. Obstet Gynecol. 1975; 46:165–168.

12. Schiff I, Tulchinsky D, Cramer D, Ryan KJ. Oral medroxyprogesterone in the treatment of postmenopausal symptoms. JAMA. 1980; 244:1443–1445.

13. Barton DL, Loprinzi CL, Quella SK, Sloan JA, Veeder MH, Egner JR, et al. Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol. 1998; 16:495–500.

14. Loprinzi CL, Kugler JW, Sloan JA, Mailliard JA, LaVasseur BI, Barton DL, et al. Venlafaxine in management of hot flashes in survivors of breast cancer: a randomised controlled trial. Lancet. 2000; 356:2059–2063.

15. Loprinzi CL, Barton DL, Sloan JA, Zahasky KM, Smith DA, Pruthi S, et al. Pilot evaluation of gabapentin for treating hot flashes. Mayo Clin Proc. 2002; 77:1159–1163.

16. Laufer LR, Erlik Y, Meldrum DR, Judd HL. Effect of clonidine on hot flashes in postmenopausal women. Obstet Gynecol. 1982; 60:583–586.

17. Lebherz TB, French L. Nonhormonal treatment of the menopausal syndrome. A double-blind evaluation of an autonomic system stabilizer. Obstet Gynecol. 1969; 33:795–799.