3. World Health Organization (WHO). Infertility: a tabulation of available data on prevalence of primary and secondary infertility. WHO/MCH/91.9 [Internet]. c2013. cited 2013 Jan 16. Geneva: WHO, Division of Family Health, Programme on Maternal and Child Health and Family Planning;Available from:
http://whqlibdoc.who.int/hq/1991/WHO_MCH_91.9.pdf.
4. Mascarenhas MN, Flaxman SR, Boerma T, Vanderpoel S, Stevens GA. National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys. PLoS Med. 2012. 9:e1001356.
5. Comhaire FH, Rowe PJ, Farley TM. The effect of doxycycline in infertile couples with male accessory gland infection: a double blind prospective study. Int J Androl. 1986. 9:91–98.
6. Christiansen E, Tollefsrud A, Purvis K. Sperm quality in men with chronic abacterial prostatovesiculitis verified by rectal ultrasonography. Urology. 1991. 38:545–549.
7. Giamarellou H, Tympanidis K, Bitos NA, Leonidas E, Daikos GK. Infertility and chronic prostatitis. Andrologia. 1984. 16:417–422.
8. Mazzoli S, Cai T, Addonisio P, Bechi A, Mondaini N, Bartoletti R. Chlamydia trachomatis infection is related to poor semen quality in young prostatitis patients. Eur Urol. 2010. 57:708–714.
9. Rybar R, Prinosilova P, Kopecka V, Hlavicova J, Veznik Z, Zajicova A, et al. The effect of bacterial contamination of semen on sperm chromatin integrity and standard semen parameters in men from infertile couples. Andrologia. 2012. 44:Suppl 1. 410–418.
10. Carne CA, Chilcott S, Palmer C, Green O, Bridge S, Walsh R, et al. Low sperm counts in genitourinary medicine clinic attendees: results from a case-control study. Sex Transm Infect. 2012. 88:422–426.
11. Gunyeli I, Abike F, Dunder I, Aslan C, Tapısız OL, Temizkan O, et al. Chlamydia, Mycoplasma and Ureaplasma infections in infertile couples and effects of these infections on fertility. Arch Gynecol Obstet. 2011. 283:379–385.
12. Cengiz T, Aydoganli L, Baykam M, Mungan NA, Tuncbilek E, Dincer M, et al. Chlamydial infections and male infertility. Int Urol Nephrol. 1997. 29:687–693.
13. Gallegos G, Ramos B, Santiso R, Goyanes V, Gosalvez J, Fernandez JL. Sperm DNA fragmentation in infertile men with genitourinary infection by Chlamydia trachomatis and Mycoplasma. Fertil Steril. 2008. 90:328–334.
14. Gdoura R, Keskes-Ammar L, Bouzid F, Eb F, Hammami A, Orfila J. Chlamydia trachomatis and male infertility in Tunisia. Eur J Contracept Reprod Health Care. 2001. 6:102–107.
15. Kokab A, Akhondi MM, Sadeghi MR, Modarresi MH, Aarabi M, Jennings R, et al. Raised inflammatory markers in semen from men with asymptomatic chlamydial infection. J Androl. 2010. 31:114–120.
16. Vigil P, Morales P, Tapia A, Riquelme R, Salgado AM. Chlamydia trachomatis infection in male partners of infertile couples: incidence and sperm function. Andrologia. 2002. 34:155–161.
17. Joki-Korpela P, Sahrakorpi N, Halttunen M, Surcel HM, Paavonen J, Tiitinen A. The role of Chlamydia trachomatis infection in male infertility. Fertil Steril. 2009. 91:4 Suppl. 1448–1450.
18. Ochsendorf FR, Ozdemir K, Rabenau H, Fenner T, Oremek R, Milbradt R, et al. Chlamydia trachomatis and male infertility: chlamydia-IgA antibodies in seminal plasma are C. trachomatis specific and associated with an inflammatory response. J Eur Acad Dermatol Venereol. 1999. 12:143–152.
19. Hosseinzadeh S, Brewis IA, Eley A, Pacey AA. Co-incubation of human spermatozoa with Chlamydia trachomatis serovar E causes premature sperm death. Hum Reprod. 2001. 16:293–299.
21. Health Protection Agency. Health protection report (weekly report). Volume 6 Number 22 Published on: 1 June 2012 [Internet]. c2013. cited 2013 Jan 30. London: Health Protection Agency;Available from:
http://www.hpa.org.uk/hpr/archives/2012/hpr2212.pdf.
22. Harkness AH. The pathology of gonorrhoea. Br J Vener Dis. 1948. 24:137–147.
23. Michelson HE. Syphilis of the epididymis. JAMA. 1919. 73:1431–1433.
24. Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Koelle DM, et al. Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes. Proc Natl Acad Sci U S A. 2010. 107:18973–18978.
25. Wald A, Zeh J, Selke S, Warren T, Ryncarz AJ, Ashley R, et al. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N Engl J Med. 2000. 342:844–850.
26. Fleming DT, McQuillan GM, Johnson RE, Nahmias AJ, Aral SO, Lee FK, et al. Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med. 1997. 337:1105–1111.
27. el Borai N, Inoue M, Lefevre C, Naumova EN, Sato B, Yamamura M. Detection of herpes simplex DNA in semen and menstrual blood of individuals attending an infertility clinic. J Obstet Gynaecol Res. 1997. 23:17–24.
28. Bezold G, Politch JA, Kiviat NB, Kuypers JM, Wolff H, Anderson DJ. Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia. Fertil Steril. 2007. 87:1087–1097.
29. Kapranos N, Petrakou E, Anastasiadou C, Kotronias D. Detection of herpes simplex virus, cytomegalovirus, and Epstein-Barr virus in the semen of men attending an infertility clinic. Fertil Steril. 2003. 79:Suppl 3. 1566–1570.
30. Kotronias D, Kapranos N. Detection of herpes simplex virus DNA in human spermatozoa by in situ hybridization technique. In Vivo. 1998. 12:391–394.
31. Bezold G, Schuster-Grusser A, Lange M, Gall H, Wolff H, Peter RU. Prevalence of human herpesvirus types 1-8 in the semen of infertility patients and correlation with semen parameters. Fertil Steril. 2001. 76:416–418.
32. Kundsin RB, Falk L, Hertig AT, Horne HW Jr. Acyclovir treatment of twelve unexplained infertile couples. Int J Fertil. 1987. 32:200–204.
33. El Borai N, LeFevre C, Inoue M, Naumova EN, Sato K, Suzuki S, et al. Presence of HSV-1 DNA in semen and menstrual blood. J Reprod Immunol. 1998. 41:137–147.
34. Corey L, Wald A, Patel R, Sacks SL, Tyring SK, Warren T, et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med. 2004. 350:11–20.
35. Dunne EF, Unger ER, Sternberg M, McQuillan G, Swan DC, Patel SS, et al. Prevalence of HPV infection among females in the United States. JAMA. 2007. 297:813–819.
36. Lai YM, Lee JF, Huang HY, Soong YK, Yang FP, Pao CC. The effect of human papillomavirus infection on sperm cell motility. Fertil Steril. 1997. 67:1152–1155.
37. Rintala MA, Grenman SE, Pollanen PP, Suominen JJ, Syrjanen SM. Detection of high-risk HPV DNA in semen and its association with the quality of semen. Int J STD AIDS. 2004. 15:740–743.
38. Tanaka H, Karube A, Kodama H, Fukuda J, Tanaka T. Mass screening for human papillomavirus type 16 infection in infertile couples. J Reprod Med. 2000. 45:907–911.
39. Townsend CL, Cortina-Borja M, Peckham CS, de Ruiter A, Lyall H, Tookey PA. Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006. AIDS. 2008. 22:973–981.
40. Shevchuk MM, Pigato JB, Khalife G, Armenakas NA, Fracchia JA. Changing testicular histology in AIDS: its implication for sexual transmission of HIV. Urology. 1999. 53:203–208.
41. Crum-Cianflone NF, Bavaro M, Hale B, Amling C, Truett A, Brandt C, et al. Erectile dysfunction and hypogonadism among men with HIV. AIDS Patient Care STDS. 2007. 21:9–19.
42. Crittenden JA, Handelsman DJ, Stewart GJ. Semen analysis in human immunodeficiency virus infection. Fertil Steril. 1992. 57:1294–1299.
43. Nicopoullos JD, Almeida PA, Ramsay JW, Gilling-Smith C. The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing. Hum Reprod. 2004. 19:2289–2297.
44. Bujan L, Hollander L, Coudert M, Gilling-Smith C, Vucetich A, Guibert J, et al. Safety and efficacy of sperm washing in HIV-1-serodiscordant couples where the male is infected: results from the European CREAThE network. AIDS. 2007. 21:1909–1914.
45. Kato S, Hanabusa H, Kaneko S, Takakuwa K, Suzuki M, Kuji N, et al. Complete removal of HIV-1 RNA and proviral DNA from semen by the swim-up method: assisted reproduction technique using spermatozoa free from HIV-1. AIDS. 2006. 20:967–973.
46. Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012. 367:399–410.
49. Fakoya A, Lamba H, Mackie N, Nandwani R, Brown A, Bernard E, et al. British HIV Association, BASHH and FSRH guidelines for the management of the sexual and reproductive health of people living with HIV infection 2008. HIV Med. 2008. 9:681–720.
50. Sutton M, Sternberg M, Koumans EH, McQuillan G, Berman S, Markowitz L. The prevalence of Trichomonas vaginalis infection among reproductive-age women in the United States, 2001-2004. Clin Infect Dis. 2007. 45:1319–1326.
51. Tuttle JP Jr, Holbrook TW, Derrick FC. Interference of human spermatozoal motility by trichomonas vaginalis. J Urol. 1977. 118:1024–1025.
52. Jarecki-Black JC, Lushbaugh WB, Golosov L, Glassman AB. Trichomonas vaginalis: preliminary characterization of a sperm motility inhibiting factor. Ann Clin Lab Sci. 1988. 18:484–489.
53. Gopalkrishnan K, Hinduja IN, Kumar TC. Semen characteristics of asymptomatic males affected by Trichomonas vaginalis. J In Vitro Fert Embryo Transf. 1990. 7:165–167.
54. Daly JJ, Sherman JK, Green L, Hostetler TL. Survival of Trichomonas vaginalis in human semen. Genitourin Med. 1989. 65:106–108.
57. Centers for Disease Control and Prevention. 2010 sexually transmitted diseases surveillance [Internet]. cited 2013 Jan 30. Atlanta: Centers for Disease Control and Prevention;Available from:
http://www.cdc.gov/std/stats10/syphilis.htm.
58. Cheng L, Bostwick DG, editors. Essentials of anatomic pathology. 2002. Totowa: Humana Press.
60. Mehik A, Hellstrom P, Sarpola A, Lukkarinen O, Jarvelin MR. Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int. 2001. 88:35–38.
61. Brookes JL, Haywood S, Green J. Adjustment to the psychological and social sequelae of recurrent genital herpes simplex infection. Genitourin Med. 1993. 69:384–387.
62. Catotti DN, Clarke P, Catoe KE. Herpes revisited. Still a cause of concern. Sex Transm Dis. 1993. 20:77–80.
63. Rosenthal SL, Zimet GD, Leichliter JS, Stanberry LR, Fife KH, Tu W, et al. The psychosocial impact of serological diagnosis of asymptomatic herpes simplex virus type 2 infection. Sex Transm Infect. 2006. 82:154–157.
64. Carney O, Ross E, Ikkos G, Mindel A. The effect of suppressive oral acyclovir on the psychological morbidity associated with recurrent genital herpes. Genitourin Med. 1993. 69:457–459.
65. Conaglen HM, Hughes R, Conaglen JV, Morgan J. A prospective study of the psychological impact on patients of first diagnosis of human papillomavirus. Int J STD AIDS. 2001. 12:651–658.
66. Maw RD, Reitano M, Roy M. An international survey of patients with genital warts: perceptions regarding treatment and impact on lifestyle. Int J STD AIDS. 1998. 9:571–578.
67. Reed BD, Ruffin MT, Gorenflo DW, Zazove P. The psychosexual impact of human papillomavirus cervical infections. J Fam Pract. 1999. 48:110–116.
68. Clarke P, Ebel C, Catotti DN, Stewart S. The psychosocial impact of human papillomavirus infection: implications for health care providers. Int J STD AIDS. 1996. 7:197–200.
69. Lamba H, Goldmeier D, Mackie NE, Scullard G. Antiretroviral therapy is associated with sexual dysfunction and with increased serum oestradiol levels in men. Int J STD AIDS. 2004. 15:234–237.
70. Goldmeier D, Scullard G, Kapembwa M, Lamba H, Frize G. Does increased aromatase activity in adipose fibroblasts cause low sexual desire in patients with HIV lipodystrophy? Sex Transm Infect. 2002. 78:64–66.