Korean J Gastroenterol.  2018 Dec;72(6):286-294. 10.4166/kjg.2018.72.6.286.

Female Gender is a Poor Predictive Factor of Functional Dyspepsia Resolution after Helicobacter pylori Eradication: A Prospective, Multi-center Korean Trial

  • 1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
  • 2Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. nayoungkim49@empas.com
  • 3Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.
  • 4Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • 5Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
  • 6Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.
  • 7Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
  • 8Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
  • 9Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  • 10Department of Internal Medicine and Research Institute, Soonchunhyang University College of Medicine, Bucheon, Korea.
  • 11Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
  • 12Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea.
  • 13Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 14Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.


The predictive factors of functional dyspepsia (FD) remain controversial. Therefore, we sought to investigate symptom responses in FD patients after Helicobacter pylori (H. pylori) eradication and used predictive factor analysis to identify significant factors of FD resolution at one-year after commencing eradication therapy.
This prospective, multi-center clinical trial was performed on 65 FD patients that met Rome III criteria and had H. pylori infection. Symptom responses and factors that predicted poor response were determined by analysis one year after commencing H. pylori eradication therapy.
A total of 63 patients completed the one-year follow-up. When an eradication success group (n=60) and an eradication failure group (n=3) were compared with respect to FD response rate at one year, results were as follows; complete response 73.3% and 0.0%, satisfactory response 1.7% and 0.0%, partial response 10.0% and 33.3%, and refractory response 15.0% and 66.7%, respectively (p=0.013). Univariate analysis showed persistent H. pylori infection (p=0.021), female gender (p=0.025), and medication for FD during the study period (p=0.013) were associated with poor FD response at one year. However, age, smoking, alcohol consumption, and underlying disease were not found to affect response. Finally, multivariate analysis showed that female gender (OR, 4.70; 95% CI, 1.17-18.88) was the sole independent risk factor of poor FD response at one year after commencing H. pylori eradication therapy.
Female gender was found to predict poor response in FD patients despite H. pylori eradication. Furthermore, successful H. pylori eradication appears to be associated with FD improvement, but the number of non-eradicated patients was too small to conclude.


Helicobacter pylori; Dyspepsia; Female; Symptom assessment

MeSH Terms

Alcohol Drinking
Follow-Up Studies
Helicobacter pylori*
Multivariate Analysis
Prospective Studies*
Risk Factors
Symptom Assessment
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