J Korean Med Sci.
2018 Dec;33(53):e342. 10.3346/jkms.2018.33.e342.
Clinical Validation of a Protein Biomarker Panel for Non-Small Cell Lung Cancer
- Affiliations
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- 1Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ccm9607@gmail.com
- 2Health Promotion Center, Asan Medical Center, Seoul, Korea.
- 3Department of Internal Medicine, Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun, Korea.
- 4Aptamer Sciences Inc., Pohang, Korea.
- 5Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- KMID: 2429891
- DOI: http://doi.org/10.3346/jkms.2018.33.e342
Abstract
- We validated the diagnostic performance of a previously developed blood-based 7-protein biomarker panel, AptoDetect™-Lung (Aptamer Sciences Inc., Pohang, Korea) using modified aptamer-based proteomic technology for lung cancer detection. Non-small cell lung cancer (NSCLC), 200 patients and benign nodule controls, 200 participants were enrolled. In a high-risk population corresponding to ≥ 55 years of age and ≥ 30 pack-years, the diagnostic performance was improved, showing 73.3% sensitivity and 90.5% specificity with an area under the curve of 0.88. AptoDetect™-Lung (Aptamer Sciences Inc.) offers the best validated performance to discriminate NSCLC from benign nodule controls in a high-risk population and could play a complementary role in lung cancer screening.
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