Yonsei Med J.
2004 Apr;45(2):359-361.
Cloning of TLR3 Isoform
- Affiliations
-
- 1Department of Microbiology, Yonsei University College of Medicine, Seoul, Korea. inhong@yumc.yonsei.ac.kr
- 2Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.
- 3Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea.
Abstract
- Toll-like receptor (TLR) 3 is a member of the TLR family that confers innate immunity by recognizing viral pathogens. Herein, we report that the TLR3 isoform is expressed on human primary cells and cell lines. This isoform has 2, 520 bp cDNAs compared to the 2, 712 bp of full cDNA, is produced by deletion of an intron-like sequence within exon 4 and is co-expressed with wild type TLR3 in primary human astrocytes and glioblastoma cell lines. This finding suggests the TLR3 isoform in astrocytes may have a different immunological role for binding ligands during the immune response in brain.
