Psychiatry Investig.  2018 Nov;15(11):1094-1097. 10.30773/pi.2018.09.20.

BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome

• Kang HJ
• Bae KY
• Kim SW
• Shin IS
• Hong YJ
• Ahn Y
• Jeong MH
• Yoon JS
• Kim JM

• KMID: 2427578
• DOI: http://doi.org/10.30773/pi.2018.09.20

Abstract

OBJECTIVE
Patients with acute coronary syndrome (ACS) are at an increased risk of suicide. It is well known that epigenetic mechanisms may explain the pathophysiology of suicidal behavior including suicidal ideation (SI), but no study has explored these mechanisms in ACS populations.
METHODS
In total, 969 patients were initially recruited within 2 weeks of the acute coronary event and, 711 patients were successfully followed up 1 year after ACS. SI was evaluated using the relevant items on the Montgomery-Ã…sberg Depression Rating Scale and covariates potentially affecting SI were estimated.
RESULTS
Brain-derived neurotrophic factor (BDNF) hypermethylation was associated with SI in both the acute and chronic phases of ACS, although the association was not statistically significant in the acute phase after applying Bonferroni's correction.
CONCLUSION
These results suggested that BDNF hypermethylation may have played a role in an epigenetic predisposition for SI in ACS patients, particularly during the chronic phase.

Keyword

Acute coronary syndrome; Suicidal ideation; Brain-derived neurotrophic factor methylation; Longitudinal study

MeSH Terms

Acute Coronary Syndrome*
Brain-Derived Neurotrophic Factor*
Depression
Epigenomics
Humans
Longitudinal Studies
Methylation*
Suicidal Ideation*
Suicide
Brain-Derived Neurotrophic Factor