Yonsei Med J.  2018 Dec;59(10):1253-1256. 10.3349/ymj.2018.59.10.1253.

Identification of Anti-Gerbich Antibody in an Emirati Marrow Hematopoietic Progenitor Cell Donor with Fy(a−b−) Phenotype

• Choi SJ
• Lee E
• Kim S
• Lyu CJ
• Kim HO

• KMID: 2426341
• DOI: http://doi.org/10.3349/ymj.2018.59.10.1253

Abstract

In this study, we report a case of anti-Gerbich (Ge) alloantibody to a high-prevalence Ge antigen in a donor with Fy(a−b−) phenotype. The alloantibody was detected in an Emirati boy who was admitted to a Korean tertiary hospital for marrow hematopoietic progenitor cell donation. He did not have a history of transfusion. His blood type was A, RhD+, and findings from the antibody screening and identification test showed 2+ reactivity in all panel cells except autologous cells. We concluded that it would be very difficult to find compatible blood components for the donor and requested further tests from external laboratories. Anti-Ge2 was identified by additional tests in a foreign reference laboratory, and the Duffy genotype of the donor was FY*02/FY*02N.01 based on the Korean Rare Blood Program. Although the donor was not a Korean, as the number of foreign patients visiting Korea increases annually, there is growing interest in patients with rare blood types in the Korean population. However, there has been very little research on rare or high prevalence blood type antigen and antibody in the Korean population. Therefore, additional research in Korea is needed on rare blood group antibodies and antigens, including Ge cases.

Keyword

Gerbich; Duffy; blood group; transfusion; reference laboratory

MeSH Terms

Antibodies
Bone Marrow*
Genotype
Hematopoietic Stem Cells*
Humans
Korea
Male
Mass Screening
Phenotype*
Prevalence
Tertiary Care Centers
Tissue Donors*
Antibodies

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