Radiat Oncol J.  2018 Sep;36(3):241-247. 10.3857/roj.2018.00171.

Evaluation of the hybrid-dynamic conformal arc therapy technique for radiotherapy of lung cancer

• Kim SJ
• Lee JW
• Kang MK
• Kim JC
• Lee JE
• Park SH
• Kim MY
• Lee SJ
• Moon SH
• Ko BS

• KMID: 2426301
• DOI: http://doi.org/10.3857/roj.2018.00171

Abstract

PURPOSE
A hybrid-dynamic conformal arc therapy (HDCAT) technique consisting of a single half-rotated dynamic conformal arc beam and static field-in-field beams in two directions was designed and evaluated in terms of dosimetric benefits for radiotherapy of lung cancer.
MATERIALS AND METHODS
This planning study was performed in 20 lung cancer cases treated with the VERO system (BrainLAB AG, Feldkirchen, Germany). Dosimetric parameters of HDCAT plans were compared with those of three-dimensional conformal radiotherapy (3D-CRT) plans in terms of target volume coverage, dose conformity, and sparing of organs at risk.
RESULTS
HDCAT showed better dose conformity compared with 3D-CRT (conformity index: 0.74 ± 0.06 vs. 0.62 ± 0.06, p < 0.001). HDCAT significantly reduced the lung volume receiving more than 20 Gy (V20: 21.4% ± 8.2% vs. 24.5% ± 8.8%, p < 0.001; V30: 14.2% ± 6.1% vs. 15.1% ± 6.4%, p = 0.02; V40: 8.8% ± 3.9% vs. 10.3% ± 4.5%, p < 0.001; and V50: 5.7% ± 2.7% vs. 7.1% ± 3.2%, p < 0.001), V40 and V50 of the heart (V40: 5.2 ± 3.9 Gy vs. 7.6 ± 5.5 Gy, p < 0.001; V50: 1.8 ± 1.6 Gy vs. 3.1 ± 2.8 Gy, p = 0.001), and the maximum spinal cord dose (34.8 ± 9.4 Gy vs. 42.5 ± 7.8 Gy, p < 0.001) compared with 3D-CRT.
CONCLUSIONS
HDCAT could achieve highly conformal target coverage and reduce the doses to critical organs such as the lung, heart, and spinal cord compared to 3D-CRT for the treatment of lung cancer patients.

Keyword

Lung neoplasms; Radiotherapy planning; Three-dimensional conformal radiotherapy; Arc therapy

MeSH Terms

Heart
Humans
Lung Neoplasms*
Lung*
Organs at Risk
Radiotherapy*
Radiotherapy, Conformal
Spinal Cord