J Korean Pain Soc.
1998 Oct;11(2):194-200.
L - NAME Inhibits Hyperalgesia Induced by Freund's Complete Adjuvant in Rat Paw
- Affiliations
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- 1Department of Anesthesiology, University of Ulsan College of Medicine, Seoul, Korea.
- 2Department of Physiology, University of Yonsei College of Medicine, Seoul, Korea.Korea.
- 3Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, U.S.A.
Abstract
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BACKGROUND: Effect of nitric oxide on the hyperalgesia induced by inflammation is controversial. We attempted to find out
the peripheral effects of nitric oxide (NO) on hyperalgesia induced by Freund's eomplete adjuvant (FCA) induced inflammation.
METHODS
Male Sprague Dawley rats were divided into three groups; control, low dose NG-nitro- L-arginine methyl ester (L-NAME, 500 ug), high dose L-NAME (5 mg). Inflammation was induced by injecting 0.l ml of PCA intraplantarly, which shows typical hyperalgesia within twelve hours after injection and maintamed for about one week. Drugs were injected 2 hours before, just before, and 3, 6, 9, 12 hours after the injection of FCA. Effect of L-NAME on hyperalgesia was assessed by measuring mechanical hyperalgesia and spontaneous pain for 3 days.
RESULTS
When injected at the site of inflammation, L-NAME caused dose dependent reduction of sponlaneous hyperalgesia. Mechanical hyperalgesia was also reduced by high dose L-NAME (p<0.05). After syslemic injection of high dose L-NAME in the back, no significant difference was noticed.
CONCLUSIONS
This suggest that L-NAME reduces FCA induced hyperalgesia via peripheral action.
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