Korean Circ J.  1986 Dec;16(4):443-451.

Acute Hemodynamic Effects of IV Nitroglycerin in the Patients with Chronic Pulmonary Hypertension

• Jeong MH
• Kim SG
• Park SJ
• Yang SJ
• Shin SC
• Park JC
• Kang JC
• Park OK

Abstract

To evaluate the acute hemodynamic effects of the intravenous nitroglycerin on the chronic pulmonary hypertension, the changes of cardiac output, pulmonary and systemic vascular resistance were simultaneously measured before and after the administration of intravenous nitroglcerin(Nitro Pohl Infus, 100ug bolus) in ten patients with pulmonary hypertension(group A) caused by various cardiac disease and fifteen patients without pulmonary hypertension (group B). A Swan-Ganz thermodilution catheter was placed so that the distal end is in the right pulmonary artery and the proximal opening in the right atrium, and a pistal catheter was placed in the ascending aorta. Continuous recording of the pulmonary arterial and aortic pressures were made during and after the injection of the nitroglycerin and cardiac output was measured by thermodilution method before and after intraveous nitroglycerin. The results were as follws: 1) Mean pulmonary arterial after pressure, aortic pressure and the lenght of cardiac cycle were significantly decreased after intravenous nitroglycerin in both groups(P<0.01). 2) Cardiac output was slightly increased but not meaningfully in group A(0.03p

MeSH Terms

Aorta
Arterial Pressure
Cardiac Output
Catheters
Heart Atria
Heart Diseases
Hemodynamics*
Humans
Hypertension, Pulmonary*
Nitroglycerin*
Pulmonary Artery
Thermodilution
Vascular Resistance
Nitroglycerin