J Liver Cancer.  2018 Sep;18(2):115-120. 10.17998/jlc.18.2.115.

Postoperative Chemoradiotherapy for R1 Resected Intrahepatic Cholangiocarcinoma

Affiliations
  • 1Department of Radiation Oncology, Dongnam Institute of Radiological and Medical Sciences, Busan, Korea.
  • 2Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.
  • 3Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Korea. kyubokim.ro@gmail.com
  • 4Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
  • 5Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea. ekchie93@snu.ac.kr

Abstract

BACKGROUND/AIMS
To investigative the potential role of postoperative chemoradiotherapy (CCRT) after R1 resection of intrahepatic cholangiocarcinoma (IHCC).
METHODS
Between January 2000 and December 2012, medical records of 18 patients who underwent curative surgery with R1 resection for IHCC were retrospectively reviewed.
RESULTS
Median age was 68 years and 12 patients (66.7%) were male. Median tumor size was 5.0 cm (range, 2.2-11.0) and 12 patients (66.7%) had T3 or higher disease. Lymph nodes were involved in four patients (22.2%). Vascular invasion and perineural invasion were present in 10 (55.6%) and 12 patients (66.7%), respectively. Postoperative CCRT given with 5-fluorouracil or gemcitabine were delivered to 7 patients (38.9%). Median radiation dose was 50.4 Gy (range, 45-54). Univariate analysis showed that median loco-regional recurrence-free survival (LRRFS), progression-free survival (PFS) and overall survival (OS) were prolonged for patients treated with CCRT (median LRRFS; 5.6 months vs. not reached, P < 0.001, median PFS; 5.6 vs. 8.3 months, P=0.047, median OS; 15.0 vs. 26.6 months, P=0.064).
CONCLUSIONS
Postoperative CCRT improved the loco-regional control and PFS in IHCC patients with R1 resection. Further study is warranted to validate the role of postoperative CCRT for these patients.

Keyword

Intrahepatic cholangiocarcinoma; R1 resection; Chemoradiotherapy

MeSH Terms

Chemoradiotherapy*
Cholangiocarcinoma*
Disease-Free Survival
Fluorouracil
Humans
Lymph Nodes
Male
Medical Records
Retrospective Studies
Fluorouracil
Full Text Links
  • JLC
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr