Ann Pediatr Endocrinol Metab.  2018 Sep;23(3):141-147. 10.6065/apem.2018.23.3.141.

Thyroid function in obese Korean children and adolescents: Korea National Health and Nutrition Examination Survey 2013–2015

• An YM
• Moon SJ
• Kim SK
• Suh YJ
• Lee JE

• KMID: 2422478
• DOI: http://doi.org/10.6065/apem.2018.23.3.141

Abstract

PURPOSE
In recent years, there has been an increasing focus on thyroid function in pediatric obese patients, but no nationwide study evaluating the relationship between thyroid function and obesity has yet been conducted in Korea. We aimed to evaluate thyroid dysfunction in obese Korean children.
METHODS
We analyzed the associations between obesity and thyroid hormone levels among 975 Korean boys and girls aged 10-18 years and who participated in the Korean National Health and Nutrition Examination Survey VI (2013-2015).
RESULTS
Average serum thyrotropin (TSH) and serum free thyroxine (fT4) levels in the nonobese group were 2.7±0.1 μIU/mL and 1.3±0.0 ng/dL, respectively, and those in the overweight group were 3.1±0.2 μIU/mL and 1.2±0.0 ng/dL. Serum TSH level was significantly higher in the abdominal obesity group than in the normal group (P=0.023). fT4 level was significantly lower in both the overweight and abdominal obesity groups than in the normal group (P < 0.001, P=0.014). Serum TSH level was associated positively with abdominal obesity and levels of high-density lipoprotein cholesterol and triglyceride. Serum fT4 level was negatively correlated with abdominal obesity (P=0.014).
CONCLUSIONS
Korean children with abdominal obesity showed increased TSH and decreased fT4 levels compared to normal children.

Keyword

Obesity; Abdominal obesity; Thyroid hormone; Child

MeSH Terms

Adolescent*
Child*
Cholesterol
Female
Humans
Korea*
Lipoproteins
Nutrition Surveys*
Obesity
Obesity, Abdominal
Overweight
Thyroid Gland*
Thyrotropin
Thyroxine
Triglycerides
Cholesterol
Lipoproteins
Thyrotropin
Thyroxine

Figure

• 

  Fig. 1. Prevalence of the subjects with obesity* who 10–18 years old children in the Korea National Health and Nutrition Examination Survey IV (2013–2015). *Using 2007 Korean national growth chart, obesity defined body mass index ≥ 95th percentile

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