Allergy Asthma Immunol Res.  2018 Jul;10(4):354-362. 10.4168/aair.2018.10.4.354.

Microbiome in the Gut-Skin Axis in Atopic Dermatitis

• Lee SY
• Lee E
• Park YM
• Hong SJ

• KMID: 2421669
• DOI: http://doi.org/10.4168/aair.2018.10.4.354

Abstract

The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD.

Keyword

Atopic dermatitis; gut microbiota; skin; microbiome

MeSH Terms

Dermatitis, Atopic*
Dysbiosis
Gastrointestinal Microbiome
Homeostasis
Immune System
Microbiota*
Skin
Skin Diseases

Figure

• 

  Figure Mechanisms of the interaction between the gut and skin microbiomes on AD. AD, atopic dermatitis; GABA, γ-aminobutyric acid; SCFA, short-chain fatty acid; 12,13-DiHome, 12,13-dihydroxy-9Z-octadecenoic acid; Treg, regulatory T; IFN, interferon; IL, interleukin.

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