Allergy Asthma Respir Dis.  2018 Sep;6(Suppl 1):S40-S43. 10.4168/aard.2018.6.S1.S40.

Current research status of pediatric atopic dermatitis in Korea

Affiliations
  • 1Department of Pediatrics, Pediatric Allergy and Respiratory Center, Soonchunhyang University Seoul Hospital, Seoul, Korea. bypyun@schmc.ac.kr

Abstract

Atopic dermatitis (AD) is a common allergic inflammatory skin disorder that occurs primarily in children, with a prevalence of 10% to 20% of children worldwide. Genetic factors, environmental factors, immune dysfunction and skin barrier dysfunction play a role in its development. Because there are no definitive laboratory tests, the diagnosis of AD is made based on a combination of clinical symptoms. Since "˜The Study Group for Atopic Dermatitis' in Korean Academy of Pediatric Allergy and Respiratory Diseases was established in 2003, references regarding research and clinical trials for AD have been increasing. However, those studies were mostly limited to pathogenesis, etiology and clinical symptoms. Education of patients and family members regarding the pathogenesis, treatment goal, prognosis of the disease plays an extremely important role in managing and improving the quality of life of AD. For the personalized, optimizing and communicating management plans, more studies focused on the phenotype of AD and new therapeutic strategies are required.

Keyword

Atopic dermatitis; Pediatric; Research

MeSH Terms

Child
Dermatitis, Atopic*
Diagnosis
Humans
Hypersensitivity
Immunologic Factors
Korea*
Patient Education as Topic
Phenotype
Prevalence
Prognosis
Quality of Life
Skin
Immunologic Factors

Cited by  1 articles

The publication of the 30th anniversary journal of Korean Academy of Pediatric Allergy and Respiratory Disease
Yeong-Ho Rha
Allergy Asthma Respir Dis. 2018;6(Suppl 1):S1-S2.    doi: 10.4168/aard.2018.6.S1.S1.


Reference

1. Schneider L, Tilles S, Lio P, Boguniewicz M, Beck L, LeBovidge J, et al. Atopic dermatitis: a practice parameter update 2012. J Allergy Clin Immunol. 2013; 131:295–299. 299.e1–299.e27.
2. Park YM, Lee SY, Kim WK, Han MY, Kim J, Chae Y, et al. Risk factors of atopic dermatitis in Korean schoolchildren: 2010 international study of asthma and allergies in childhood. Asian Pac J Allergy Immunol. 2016; 34:65–72.
Article
3. Eichenfield LF, Tom WL, Chamlin SL, Feldman SR, Hanifin JM, Simpson EL, et al. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. J Am Acad Dermatol. 2014; 70:338–351.
4. Ricci G, Patrizi A, Baldi E, Menna G, Tabanelli M, Masi M. Long-term follow-up of atopic dermatitis: retrospective analysis of related risk factors and association with concomitant allergic diseases. J Am Acad Dermatol. 2006; 55:765–771.
Article
5. Lee SI, Shin MH, Lee HB, Lee JS, Son BK, Koh YY, et al. Prevalences of symptoms of asthma and other allergic diseases in korean children: a nationwide questionnaire survey. J Korean Med Sci. 2001; 16:155–164.
Article
6. Oh JW, Pyun BY, Choung JT, Ahn KM, Kim CH, Song SW, et al. Epidemiological change of atopic dermatitis and food allergy in school-aged children in Korea between 1995 and 2000. J Korean Med Sci. 2004; 19:716–723.
Article
7. Yu JS, Lee CJ, Lee HS, Kim J, Han Y, Ahn K, et al. Prevalence of atopic dermatitis in Korea: analysis by using national statistics. J Korean Med Sci. 2012; 27:681–685.
Article
8. Ahn K. The prevalence of atopic dermatitis in Korean children. Allergy Asthma Immunol Res. 2016; 8:1–2.
Article
9. Lee JH, Han KD, Kim KM, Park YG, Lee JY, Park YM. Prevalence of atopic dermatitis in Korean children based on data from the 2008–2011 Korean National Health and Nutrition Examination Survey. Allergy Asthma Immunol Res. 2016; 8:79–83.
Article
10. Yu HS, Kang MJ, Jung YH, Kim HY, Seo JH, Kim YJ, et al. Mutations in the filaggrin are predisposing factor in Korean children with atopic dermatitis. Allergy Asthma Immunol Res. 2013; 5:211–215.
Article
11. Song A, Lee JY, Yang HK, Kim M, Ahn K, Lee SI, et al. Sensitization in children with atopic dermatitis: a single center study. Allergy Asthma Respir Dis. 2016; 4:290–295.
Article
12. Jeong KY, Park JW, Hong CS. House dust mite allergy in Korea: the most important inhalant allergen in current and future. Allergy Asthma Immunol Res. 2012; 4:313–325.
Article
13. Kim J, Lee S, Woo SY, Han Y, Lee JH, Lee IY, et al. The indoor level of house dust mite allergen is associated with severity of atopic dermatitis in children. J Korean Med Sci. 2013; 28:74–79.
Article
14. Na MS, Kim GR, Ha EK, Lee SJ, Sheen YH, Choi SH, et al. Allergen sensitization and clinical characteristics in young children with atopic dermatitis. Allergy Asthma Respir Dis. 2017; 5:128–134.
Article
15. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh). 1980; 92:Suppl. 44–47.
16. Cho JE, Jeon YH, Yang HJ, Pyun BY. A study of the frequency and characteristics of minor clinical manifestations in children with atopic dermatitis. Korean J Pediatr. 2009; 52:818–823.
Article
17. Noda S, Suárez-Fariñas M, Ungar B, Kim SJ, de Guzman Strong C, Xu H, et al. The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization. J Allergy Clin Immunol. 2015; 136:1254–1264.
Article
18. Lee E, Lee SH, Kwon JW, Kim YH, Cho HJ, Yang SI, et al. Atopic dermatitis phenotype with early onset and high serum IL-13 is linked to the new development of bronchial hyperresponsiveness in school children. Allergy. 2016; 71:692–700.
Article
19. Kusunoki T, Asai K, Harazaki M, Korematsu S, Hosoi S. Month of birth and prevalence of atopic dermatitis in schoolchildren: dry skin in early infancy as a possible etiologic factor. J Allergy Clin Immunol. 1999; 103:1148–1152.
Article
20. Weiland SK, Hüsing A, Strachan DP, Rzehak P, Pearce N. ISAAC Phase One Study Group. Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med. 2004; 61:609–615.
Article
21. Byremo G, Rød G, Carlsen KH. Effect of climatic change in children with atopic eczema. Allergy. 2006; 61:1403–1410.
Article
22. Yang YS, Lee JW, Shim JW, Kim DS, Jung HL, Park MS, et al. Relationship between serum interleukin-31/25-hydroxyvitamin D levels and the severity of atopic dermatitis in children. Allergy Asthma Respir Dis. 2015; 3:396–401.
Article
23. Shin YH, Park JH, Sung MS, Kim SW. Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Allergy Asthma Respir Dis. 2014; 2:114–121.
Article
24. Baek JU, Hwangbo JW, Lee HR, Lee SY. Vitamin D insufficiency is associated with food sensitization in children under 2 years with atopic dermatitis. Allergy Asthma Respir Dis. 2013; 1:211–215.
Article
25. Min TK, Yang HJ, Lee HW, Pyun BY. Correlation between serum 25-hydroxyvitamin D levels and methicillin - resistant Staphylococcus aureus skin colonization in atopic dermatitis. Allergy Asthma Respir Dis. 2013; 1:138–143.
Article
26. Kim MH, Rho M, Choi JP, Choi HI, Park HK, Song WJ, et al. A metagenomic analysis provides a culture-independent pathogen detection for atopic dermatitis. Allergy Asthma Immunol Res. 2017; 9:453–461.
Article
27. Hong SW, Choi EB, Min TK, Kim JH, Kim MH, Jeon SG, et al. An important role of α-hemolysin in extracellular vesicles on the development of atopic dermatitis induced by Staphylococcus aureus. PLoS One. 2014; 9:e100499.
Article
28. Hong SW, Kim MR, Lee EY, Kim JH, Kim YS, Jeon SG, et al. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy. 2011; 66:351–359.
Article
29. Kim JE, Kim HJ, Lew BL, Lee KH, Hong SP, Jang YH, et al. Consensus guidelines for the treatment of atopic dermatitis in Korea (Part I): general management and topical treatment. Ann Dermatol. 2015; 27:563–577.
Article
30. Kim JE, Kim HJ, Lew BL, Lee KH, Hong SP, Jang YH, et al. Consensus guidelines for the treatment of atopic dermatitis in Korea (Part II): systemic treatment. Ann Dermatol. 2015; 27:578–592.
Article
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