Yonsei Med J.  2017 Jul;58(4):867-871. 10.3349/ymj.2017.58.4.867.

Effect of Early Plasma Exchange on Survival in Patients with Severe Fever with Thrombocytopenia Syndrome: A Multicenter Study

Affiliations
  • 1Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.
  • 2Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea. neosangtaek@naver.com
  • 3Department of Internal Medicine, Daegu Fatima Hospital, Deagu, Korea.
  • 4Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 5Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
  • 6Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
  • 7Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
  • 8Department of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • 9Department of Internal Medicine, Changwon Fatima Hospital, Changwon, Korea.

Abstract

Despite a high mortality rate, no specific treatment for severe fever with thrombocytopenia syndrome (SFTS) has been established. This study compared the clinical outcomes of SFTS patients treated with plasma exchange (PE group) with those who were not treated (non-PE group) at nine Korean hospitals between May 2013 and August 2015. A total of 53 SFTS patients were included: 24 (45.3%) PE cases and 29 (54.7%) non-PE cases. The overall in-hospital mortality rate was 32.1% (17/53). The in-hospital mortality rate of the PE group did not differ from that of the non-PE group (29.3% vs. 34.5%, p=0.680). Of the 24 PE cases, 16 (66.7%) were treated with PE within 7 days of symptom onset (early PE group). The early PE group survived longer than the non-PE group (mean 28.4 days vs. 22.6 days, p=0.044). Multivariate analysis showed an inverse association between early PE implementation and 30-day mortality (adjusted hazard ratio 0.052, 95% confidence interval 0.004-0.678, p=0.024). The results of this study suggest that early PE implementation may have a beneficial effect on the clinical outcome of SFTS patients.

Keyword

Severe fever with thrombocytopenia syndrome; Phlebovirus; plasma exchange; treatment

MeSH Terms

Aged
Female
Fever/*complications/*mortality
Humans
Male
Middle Aged
Multivariate Analysis
Plasma Exchange/*mortality
Risk Factors
Survival Analysis
Thrombocytopenia/*complications/*mortality
Treatment Outcome

Figure

  • Fig. 1 Comparison of 30-day survival between treatment groups. (A) PE group vs. non-PE group. There was no significant difference in 30-day survival between the two groups (mean survival time 24.0 days vs. 22.6 days, p=0.622 by the log-rank test). (B) Early PE group vs. non-PE group. Survival was longer in the early PE group than in the non-PE group (mean survival time 28.4 days vs. 22.6 days, p=0.044 by the log-rank test). PE, plasma exchange.


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