Yonsei Med J.  2018 Jan;59(1):107-112. 10.3349/ymj.2018.59.1.107.

Contrast-Induced Acute Kidney Injury after Coil Embolization for Aneurysmal Subarachnoid Hemorrhage

• Lee HG
• Kim WK
• Yeon JY
• Kim JS
• Kim KH
• Jeon P
• Hong SC

• KMID: 2418856
• DOI: http://doi.org/10.3349/ymj.2018.59.1.107

Abstract

PURPOSE
Contrast-induced acute kidney injury (CI-AKI) is associated with poor outcomes after percutaneous coronary intervention. However, CI-AKI has rarely been evaluated within the neurovascular field. The aim of this study was to investigate the incidence and clinical implication of CI-AKI after coil embolization in patients with an aneurysmal subarachnoid hemorrhage (aSAH).
MATERIALS AND METHODS
Between January 2005 and March 2016, 192 patients who underwent coil embolization were enrolled in this study. CI-AKI was defined as an increase from baseline serum creatinine concentration of >25% or >0.5 mg/dL within 72 hours after coil embolization. A poor clinical outcome was defined as a score of ≥3 on the modified Rankin Scale at one-year post-treatment.
RESULTS
A total of 16 patients (8.3%) died as a result of medical problems within one year. CI-AKI was identified in 14 patients (7.3%). Prominent risk factors for one-year mortality included CI-AKI [odds ratio (OR): 16.856; 95% confidence interval (CI): 3.437-82.664] and an initial Glasgow Coma Scale (GCS) score ≤8 (OR: 5.565; 95% CI: 1.703-18.184). A poor clinical outcome was associated with old age (≥65 years) (OR: 7.921; 95% CI: 2.977-21.076), CI-AKI (OR: 11.281; 95% CI: 2.138-59.525), an initial GCS score ≤8 (OR 31.02; 95% CI, 10.669-90.187), and a ruptured aneurysm (p=0.016, OR: 4.278) in posterior circulation.
CONCLUSION
CI-AKI seems to be an independent predictor of the overall outcomes of aSAH after endovascular treatment.

Keyword

Subarachnoid hemorrhage; coil embolization; outcome; contrast induced acute kidney injury; contrast induced nephropathy; prognosis

MeSH Terms

Acute Kidney Injury/*chemically induced/diagnostic imaging/*etiology/mortality
Adult
Aged
Aged, 80 and over
Aneurysm/complications/diagnostic imaging/*therapy
Angiography
Contrast Media/*adverse effects
Embolization, Therapeutic/*adverse effects
Female
Humans
Incidence
Male
Middle Aged
Subarachnoid Hemorrhage/complications/diagnostic imaging/*therapy
Treatment Outcome
Young Adult
Contrast Media

Figure

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  Fig. 1 Mortality and functional outcomes (modified Rankin Scale ≥3) in one-year after coil embolization in patients with aneurysmal subarachnoid hemorrhage. CI-AKI, contrast-induced acute kidney injury.

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