Obstet Gynecol Sci.  2017 Nov;60(6):593-597. 10.5468/ogs.2017.60.6.593.

Skin metastases in ovarian clear cell adenocarcinoma: a case report and a review of the literature

• Nam G
• Lim YM
• Cho MS
• Lee J
• Kim YH

• KMID: 2418362
• DOI: http://doi.org/10.5468/ogs.2017.60.6.593

Abstract

Epithelial ovarian carcinoma is a high mortality neoplasm in gynecologic malignancy. It usually can metastasize to distant organs such as pleura, liver, lung, and lymph nodes. However, the skin metastases are not common and related to very poor prognosis. Here we report a 54-year-old patient with ovarian clear cell carcinoma with skin metastases on the anterior chest at 11 months after initial diagnosis. Although she received palliative chemotherapy, she expired due to disease progression 2 months later after the diagnosis of skin metastases.

Keyword

Ovarian neoplasms; Adenocarcinoma, clear cell; Neoplasm metastasis; Skin neoplasms

MeSH Terms

Adenocarcinoma, Clear Cell*
Diagnosis
Disease Progression
Drug Therapy
Humans
Liver
Lung
Lymph Nodes
Middle Aged
Mortality
Neoplasm Metastasis*
Ovarian Neoplasms
Pleura
Prognosis
Skin Neoplasms
Skin*
Thorax

Figure

• 

  Fig. 1 (A) Multiple skin metastases on the anterior chest wall including bilateral breast skin: pruritus erythematous patches metastatic clear cell carcinoma in the dermis. (B) Tumor cells exhibit abundant eosinophilic cytoplasm and marked nuclear atypia in hematoxylin-eosin staining (×200), (C) hematoxylin-eosin staining (×400), (D) Immunohistochemistry for progesterone receptor is weakly positive within the metastatic clear cell carcinoma (×400).

Reference

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017; 67:7–30.

2. Dauplat J, Hacker NF, Nieberg RK, Berek JS, Rose TP, Sagae S. Distant metastases in epithelial ovarian carcinoma. Cancer. 1987; 60:1561–1566.

3. Spencer PS, Helm TN. Skin metastases in cancer patients. Cutis. 1987; 39:119–121.

4. Tharakaram S. Metastases to the skin. Int J Dermatol. 1988; 27:240–242.

5. Krumerman MS, Garret R. Carcinomas metastatic to skin. N Y State J Med. 1977; 77:1900–1903.

6. Hussein MR. Skin metastasis: a pathologist's perspective. J Cutan Pathol. 2010; 37:e1–e20.

7. Cormio G, Capotorto M, Di Vagno G, Cazzolla A, Carriero C, Selvaggi L. Skin metastases in ovarian carcinoma: a report of nine cases and a review of the literature. Gynecol Oncol. 2003; 90:682–685.

8. Kim MK, Kim SH, Lee YY, Choi CH, Kim TJ, Lee JW, et al. Metastatic skin lesions on lower extremities in a patient with recurrent serous papillary ovarian carcinoma: a case report and literature review. Cancer Res Treat. 2012; 44:142–145.

9. Matsui H, Suzuka K, Yamazawa K, Tanaka N, Mitsuhashi A, Seki K, et al. Scalp metastasis of a serous ovarian cancer. Acta Obstet Gynecol Scand. 2002; 81:577–578.

10. Lee HC, Chu CY, Hsiao CH. Carcinoma erysipeloides from ovarian clear-cell carcinoma. J Clin Oncol. 2007; 25:5828–5830.

11. Schonmann R, Altaras M, Biron T, Bernheim J, Fishman A. Inflammatory skin metastases from ovarian carcinoma--a case report and review of the literature. Gynecol Oncol. 2003; 90:670–672.

12. Reinhold RB, Lokich JJ. Electrocoagulation: palliative surgery to control metastatic cutaneous malignancy. J Surg Oncol. 1979; 11:207–212.

13. Tapley ND. Radiation therapy with the electron beam. Semin Oncol. 1981; 8:49–58.

14. Schellhas HF, Schneider DF. Hematoporphyrin derivative photoradiation therapy applied in gynecology. Colposc Gynecol Laser Surg. 1986; 2:53–59.

15. Charalampidis C, Lampaki S, Zarogoulidis P, Lazaridis G, Mpaka S, Kosmidis C, et al. Fine-needle aspiration of skin metastasis in ovarian cancer-report of two cases and review of the literature. Ann Transl Med. 2016; 4:447.