Korean J Clin Pharm.  2018 Jun;28(2):154-157. 10.24304/kjcp.2018.28.2.154.

Hyperprolactinemia after taking Levosulpiride and its Causality Assessment: An Adverse Event Reported by a Community Pharmacy

• Lee H
• Jo YJ
• Yoon JS
• Ji E

• KMID: 2416675
• DOI: http://doi.org/10.24304/kjcp.2018.28.2.154

Abstract

Levosulpiride is one of the most frequently prescribed medicines in Korea. An adverse drug reaction (ADR) after taking levosulpiride was reported at a community pharmacy in Korea. A 31-year-old woman reported the symptoms of lactation and amenorrhea after taking levosulpiride; an evaluation of whether these symptoms were caused by the medication was therefore necessary. Several tools can be used to determine if the ADR resulted from the administered drug or other factors, including the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) criteria, the Naranjo scale, and the Korean causality assessment algorithm (Ver. 2). The causality was evaluated as "possible" by the WHO-UMC and Naranjo scales, but as "probable" by the Korean causality assessment algorithm (Ver. 2). In conclusion, the information provided did not indicate definite causality and there were slight differences in the results obtained from each assessment method.

Keyword

Levosulpiride; adverse drug reaction; hyperprolactinemia; causality assessment; community pharmacy

MeSH Terms

Adult
Amenorrhea
Drug-Related Side Effects and Adverse Reactions
Female
Global Health
Humans
Hyperprolactinemia*
Korea
Lactation
Methods
Pharmacies*
Weights and Measures