Korean J Gastrointest Endosc.  2006 Sep;33(3):135-139.

Our Experience of Gastritis Cystica Profunda Cases and Its Clinical Study

• Kim YS
• Heo WS
• Chae KH
• Jung JH
• Gang YS
• Kim SH
• Seong JK
• Lee BS
• Jeong HY
• Song KS
• Shin KS
• Cho JS
• Noh SM

Abstract

BACKGROUND/AIMS: Gastritis cystica profunda (GCP) is a rare disease that is characterized by a hyperplastic and cystic dilatation of the pseudopyloric gland with submucosal invasion. GCP is regarded as a benign lesion. However, there is some controversy regarding its malignant potential. This study reviewed the clinical features and association with malignancy.
METHODS
From January 2001 to June 2005, 1,010 cases of resected and 1,228 cases of an endoscopic mucosal resection or polypectomy were examined.
RESULTS
Thirty-nine cases (1.7%) were confirmed pathologically and were not associated with prior gastric surgery mostly. The mean age was 60.0+/-11.4 years old and there were 29 male patients. The body was most commonly located on the longitudinal axis (57.1%). Eleven cases (28.2%) were not associated any other gastric lesion, the majority of which were the polypoid type (82.0%). However, two cases were found as a hypertrophic mucosal fold, and a submucosal tumor, respectively. Seventeen cases (43.6%) were associated with early gastric cancer.
CONCLUSIONS
Despite its rarity, GCP should be considered when an endoscopically polypoid lesion or submucosal tumor (SMT) is found. Because of its association with early gastric cancer or adenoma, more study will be needed to examine the relationship between GCP and gastric carcinogen

Keyword

Gastritis cystica profunda; Carcinoge

MeSH Terms

Adenoma
Axis, Cervical Vertebra
Dilatation
Gastritis*
Humans
Male
Rare Diseases
Stomach Neoplasms