J Korean Med Sci.  2018 Jun;33(23):e165. 10.3346/jkms.2018.33.e165.

Association between Plasma Pentraxin 3 Levels and Bone Mineral Density in Elderly Koreans: the Dong-gu Study

• Lee R
• Ahn HR
• Shin MH
• Kim HN
• Lee YH
• Choi SW
• Kweon SS

• KMID: 2415446
• DOI: http://doi.org/10.3346/jkms.2018.33.e165

Abstract

BACKGROUND
We investigated the association between pentraxin 3 (PTX3), a novel inflammatory marker, and bone mineral density (BMD) in the general Korean population.
METHODS
We selected a sub-cohort of 1,440 subjects (757 men and 683 women) from participants in the community-based Dong-gu Study. The mean age was 66.0 ± 8.1 years for men and 63.7 ± 7.9 years for women. The plasma PTX3 levels were measured using an enzyme-linked immunosorbent assay, and BMD was measured in the femoral neck and lumbar spine using dual-energy X-ray absorptiometry. Linear regression analyses were used to evaluate the association between the plasma PTX3 levels and BMD.
RESULTS
PTX3 was inversely associated with the BMD of the lumbar spine (P = 0.010) and femoral neck (P < 0.001) in men but not in women. For men, the association with the BMD of the femoral neck remained after adjustment for multiple comparison (P = 0.020).
CONCLUSION
This study suggests that PTX3 levels might be inversely associated with BMD in elderly men.

Keyword

Pentraxin 3; Bone Mineral Density; Korean; Elderly; Inflammatory Marker

MeSH Terms

Absorptiometry, Photon
Aged*
Bone Density*
Enzyme-Linked Immunosorbent Assay
Female
Femur Neck
Humans
Linear Models
Male
Plasma*
Spine