J Korean Assoc Oral Maxillofac Surg.  2018 Jun;44(3):93-102. 10.5125/jkaoms.2018.44.3.93.

Angiogenesis and the prevention of alveolar osteitis: a review study

• Saghiri MA
• Asatourian A
• Sheibani N

• KMID: 2414427
• DOI: http://doi.org/10.5125/jkaoms.2018.44.3.93

Abstract

Angiogenesis is one of the essential processes that occur during wound healing. It is responsible for providing immunity as well as the regenerative cells, nutrition, and oxygen needed for the healing of the alveolar socket following tooth extraction. The inappropriate removal of formed blood clots causes the undesirable phenomenon of alveolar osteitis (AO) or dry socket. In this review, we aimed to investigate whether enhanced angiogenesis contributes to a more effective prevention of AO. The potential pro- or anti-angiogenic activity of different materials used for the treatment of AO were evaluated. An electronic search was performed in the PubMed, MEDLINE, and EMBASE databases via OVID from January 2000 to September 2016 using the keywords mentioned in the PubMed and MeSH (Medical Subject Headings) terms regarding the role of angiogenesis in the prevention of AO. Our initial search identified 408 articles using the keywords indicated above, with 38 of them meeting the inclusion criteria set for this review. Due to the undeniable role of angiogenesis in the socket healing process, it is beneficial if strategies for preventing AO are directed toward more proangiogenic materials and modalities.

Keyword

Dry socket; Endothelial cells; Regeneration

MeSH Terms

Dry Socket*
Endothelial Cells
Oxygen
Regeneration
Tooth Extraction
Wound Healing
Oxygen

Figure

• 

  Fig. 1 A schematic presentation of the mechanisms of action of chlorhexidine gluconate (CHX) gel and local antibiotic agents for the prevention of alveolar osteitis (AO).

• 

  Fig. 2 A schematic presentation of the mechanisms of action of hemostatic agents placed inside the alveolar socket for the prevention of AO.(PRP: platelet-rich plasma, PRF: platelet-rich fibrin, VEGF: vascular endothelial growth factor, FGF: fibroblast growth factor, AO: alveolar osteitis)

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