J Gynecol Oncol.  2017 Nov;28(6):e82. 10.3802/jgo.2017.28.e82.

Surgical and oncologic outcomes after robotic radical hysterectomy as compared to open radical hysterectomy in the treatment of early cervical cancer

• Shah CA
• Beck T
• Liao JB
• Giannakopoulos NV
• Veljovich
• Paley P

• KMID: 2413208
• DOI: http://doi.org/10.3802/jgo.2017.28.e82

Abstract

OBJECTIVE
The use of robotic radical hysterectomy has greatly increased in the treatment of early stage cervical cancer. We sought to compare surgical and oncologic outcomes of women undergoing robotic radical hysterectomy compared to open radical hysterectomy.
METHODS
The clinic-pathologic, treatment, and recurrence data were abstracted through an Institutional Review Board-approved protocol at 2 separate large tertiary care centers in Seattle, Swedish Medical Center and the University of Washington. Data were collected from 2001-2012. Comparisons between the robotic and open cohorts were made for complications, recurrence, progression-free survival (PFS), and overall survival (OS).
RESULTS
In the study period, 109 robotic radical hysterectomies were performed. These were compared to 202 open radical hysterectomies. The groups were comparable in terms of age and body mass index (BMI). Length of stay (LOS) was considerably shorter in the robotic group (42.7 vs. 112.6 hours, p<0.001) as was estimated blood loss (EBL; 105.9 vs. 482.6 mL, p<0.001). There were more complications in the open radical hysterectomy group, 23.4% vs. 9.2% in the robotic group (p=0.002). The recurrence rate was comparable between the groups (10.1% vs. 10.4%, p=0.730). In multivariate adjusted analysis, robotic surgery was not a statistically significant predictor of PFS (p=0.230) or OS (0.85).
CONCLUSION
Our study, one of the largest multi-institution cohorts of patients undergoing robotic radical hysterectomy, suggest robotic radical hysterectomy leads to comparable oncologic outcomes in the treatment of early stage cervical cancer with improved short-term surgical outcomes such as decreased LOS and EBL.

Keyword

Early Stage Cervical Cancer; Robotic Surgery; Chemotherapy; Radiation

MeSH Terms

Adenocarcinoma/pathology/*surgery
Adult
Aged
Aged, 80 and over
Blood Transfusion/utilization
Carcinoma, Adenosquamous/pathology/*surgery
Carcinoma, Squamous Cell/pathology/*surgery
Disease-Free Survival
Female
Humans
Hysterectomy/*methods
Laparoscopy/*methods
Laparotomy/methods
Length of Stay
Middle Aged
Neoplasm Recurrence, Local/*epidemiology
Neoplasm Staging
Postoperative Complications/*epidemiology/therapy
Robotic Surgical Procedures/*methods
Survival Rate
Treatment Outcome
Tumor Burden
Uterine Cervical Neoplasms/pathology/*surgery
Young Adult