Clin Mol Hepatol.
2017 Jun;23(2):147-153. 10.3350/cmh.2016.0055.
Acute hepatitis A, B and C but not D is still prevalent in Mongolia: a time trend analysis
- Affiliations
-
- 1Department of Infectious Diseases, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
- 2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. dyk1025@yuhs.ac
- 3Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, NSW, Australia.
- 4National Center for Communicable Diseases, Ulaanbaatar, Mongolia.
- KMID: 2413118
- DOI: http://doi.org/10.3350/cmh.2016.0055
Abstract
- BACKGROUND/AIMS
Mongolia has one of the highest hepatitis A, C, B and D infection incidences worldwide. We sought to investigate changes in the proportion of acute viral hepatitis types in Mongolia over the last decade.
METHODS
The cohort comprised 546 consecutive patients clinically diagnosed with acute viral hepatitis from January 2012 to December 2014 in Ulaanbaatar Hospital, Mongolia. A time trend analysis investigating the change in proportion of acute hepatitis A virus, hepatitis C virus (HCV), hepatitis B virus (HBV) and hepatitis delta virus (HDV) infection among the cohort with respect to a previous published study was undertaken.
RESULTS
Acute hepatitis A, B and C was diagnosed in 50.9%, 26.2% and 6.0% of the cohort. Notably, 16.8% of the cohort had a dual infection. The etiologies of acute viral hepatitis were varied by age groups. The most common cause of acute viral hepatitis among 2-19 year olds was hepatitis A, HBV and superinfection with HDV among 20-40 year olds, and HCV among 40-49 year olds. Patients with more than one hepatitis virus infection were significantly older, more likely to be male and had a higher prevalence of all risk factors for disease acquisition. These patients also had more severe liver disease at presentation compared to those with mono-infection.
CONCLUSIONS
Acute viral hepatitis is still prevalent in Mongolia. Thus, the need for proper infection control is increasing in this country.
Keyword
MeSH Terms
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Acute Disease
Adolescent
Adult
Antibodies, Viral/blood
Asian Continental Ancestry Group
Child
Child, Preschool
Hepatitis A/*diagnosis/epidemiology
Hepatitis B/*diagnosis/epidemiology
Hepatitis C/*diagnosis/epidemiology
Hepatitis D/*diagnosis/epidemiology
Humans
Immunoglobulin M/blood
Middle Aged
Mongolia/epidemiology
Prevalence
Risk Factors
Young Adult
Antibodies, Viral
Immunoglobulin M
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