J Vet Sci.  2017 Sep;18(3):415-417. 10.4142/jvs.2017.18.3.415.

Clinical application of quantitative computed tomography in osteogenesis imperfecta-suspected cat

• Won S
• Chung WJ
• Yoon J

• KMID: 2412460
• DOI: http://doi.org/10.4142/jvs.2017.18.3.415

Abstract

One-year-old male Persian cat presented with multiple fractures and no known traumatic history. Marked decrease of bone radiopacity and thin cortices of all long bones were identified on radiography. Tentative diagnosis was osteogenesis imperfecta, a congenital disorder characterized by fragile bone. To determine bone mineral density (BMD), quantitative computed tomography (QCT) was performed. The QCT results revealed a mean trabecular BMD of vertebral bodies of 149.9 ± 86.5 mg/cm³. After bisphosphonate therapy, BMD of the same site increased significantly (218.5 ± 117.1 mg/cm³, p < 0.05). QCT was a useful diagnostic tool to diagnose osteopenia and quantify response to medical treatment.

Keyword

cats; metabolic bone diseases; osteogenesis imperfecta; quantitative computed tomography

MeSH Terms

Animals
Bone Density
Bone Density Conservation Agents/therapeutic use
Cat Diseases/*diagnostic imaging/pathology
Cats
Diphosphonates/therapeutic use
Male
Osteogenesis Imperfecta/diagnostic imaging/drug therapy/pathology/*veterinary
Radiography/veterinary
Tomography, X-Ray Computed/veterinary
Treatment Outcome
Bone Density Conservation Agents
Diphosphonates

Figure

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  Fig. 1 Thoracic radiography image (A), and images of left hindlimb (B) and right hindlimb (C). In (A), multiple fractures of spinal process of thoracic vertebra (white arrows) are visible. Multiple rib fractures (arrowheads) and a 3rd sternum fracture (black arrow) are also visible. The tibia and fibula are fractured bilaterally and inappropriate bone healing was suspected.

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  Fig. 2 Linear regression used for conversion of mean attenuation value (HU) to trabecular bone mineral density (tBMD) in a bone phantom. (R2 = 0.970).

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  Fig. 3 Measurement of the attenuation value (HU) for the region of interest (ROI) in the body of the 6th lumbar vertebra. An elliptical ROI in the most central transverse image was used to assess trabecular bone density.

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