Gut Liver.
2017 Mar;11(2):253-260. 10.5009/gnl16231.
Diagnostic Yield and Clinical Impact of Video Capsule Endoscopy in Patients with Chronic Diarrhea: A Korean Multicenter CAPENTRY Study
- Affiliations
-
- 1Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
- 2Department of Internal Medicine, Inje University College of Medicine, Seoul, Korea. moonjs2@unitel.co.kr
- 3Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
- 5Department of Internal Medicine, Dongguk University College of Medicine, Goyang, Korea.
- 6Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
- 7Department of Gastroenterology, University of Ulsan College of Medicine, Seoul, Korea.
- 8Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 9Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea.
- 10Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
- 11Department of Internal Medicine, Inje University College of Medicine, Busan, Korea.
- 12Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 13Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
- 14Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
- 15Department of Internal Medicine, Ajou University School of Medicine, Suwon, Korea.
- KMID: 2412192
- DOI: http://doi.org/10.5009/gnl16231
Abstract
- BACKGROUND/AIMS
In some cases, chronic diarrhea is unexplained, and small bowel disorders may be one of the causes. The aim of this study was to assess the diagnostic yield and clinical impact of video capsule endoscopy (VCE) in patients with chronic diarrhea.
METHODS
We retrospectively analyzed records from October 2002 to August 2013 in the VCE nationwide database registry (n=2,964). Ninety-one patients from 15 medical centers (60 males and 31 females; mean age, 47±19 years) were evaluated for VCE as a result of chronic diarrhea.
RESULTS
The duration of chronic diarrhea was 8.3±14.7 months. The positive diagnostic yield of VCE was 42.9% (39/91). However, 15.4% (14/91) exhibited an inconsistent result, and 41.8% (38/91) were negative. Abnormal findings consistent with chronic diarrhea included erosions/aphthous ulcers (19.8%), ulcers (17.6%), mucosal erythema (3.3%), edema (1.1%), and luminal narrowing (1.1%). The most common diagnoses were functional diarrhea associated with irritable bowel syndrome in 37 patients (40.7%) and Crohn's disease in 18 patients (19.8%). After VCE examination, the diagnosis was changed in 34.1% of the patients (31/91). Hematochezia (odds ratio [OR], 8.802; 95% confidence interval [CI], 2.126 to 36.441) and hypoalbuminemia (OR, 4.811; 95% CI, 1.241 to 18.655) are predictive factors of a positive diagnostic yield.
CONCLUSIONS
VCE had a favorable diagnostic yield and clinical impact on the management of patients with chronic diarrhea.
Keyword
MeSH Terms
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Adult
Aged
Capsule Endoscopy/methods/*statistics & numerical data
Chronic Disease
Crohn Disease/complications/diagnostic imaging
Diarrhea/*etiology
Female
Humans
Intestinal Diseases/complications/*diagnostic imaging
Irritable Bowel Syndrome/complications/diagnostic imaging
Male
Middle Aged
Predictive Value of Tests
Retrospective Studies
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