Gut Liver.  2017 Jan;11(1):27-37. 10.5009/gnl15502.

25 Years of Proton Pump Inhibitors: A Comprehensive Review

• Strand DS
• Kim D
• Peura DA

• KMID: 2412152
• DOI: http://doi.org/10.5009/gnl15502

Abstract

Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders. Although all members in this class act in a similar fashion, inhibiting active parietal cell acid secretion, there are slight differences among PPIs relating to their pharmacokinetic properties, metabolism, and Food and Drug Administration (FDA)-approved clinical indications. Nevertheless, each is effective in managing gastroesophageal reflux disease and uncomplicated or complicated peptic ulcer disease. Despite their overall efficacy, PPIs do have some limitations related to their short plasma half-lives and requirement for meal-associated dosing, which can lead to breakthrough symptoms in some individuals, especially at night. Longer-acting PPIs and technology to prolong conventional PPI activity have been developed to specifically address these limitations and may improve clinical outcomes.

Keyword

Proton pump inhibitors; Review; Pharmacokinetics; Indications; Risk

MeSH Terms

Anti-Bacterial Agents/therapeutic use
Anti-Inflammatory Agents, Non-Steroidal/adverse effects
Drug Therapy, Combination
Gastroesophageal Reflux/*drug therapy
Half-Life
Helicobacter Infections/drug therapy
Humans
Peptic Ulcer/chemically induced/*drug therapy/prevention & control
Proton Pump Inhibitors/pharmacokinetics/*therapeutic use
Anti-Bacterial Agents
Anti-Inflammatory Agents, Non-Steroidal
Proton Pump Inhibitors