Korean J Pediatr.  2018 May;61(5):160-166. 10.3345/kjp.2018.61.5.160.

Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment

• Seo YM
• Kang HM
• Lee SC
• Yu JW
• Kil HR
• Rhim JW
• Han JW
• Lee KY

• KMID: 2412143
• DOI: http://doi.org/10.3345/kjp.2018.61.5.160

Abstract

PURPOSE
This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients.
METHODS
Clinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between patients with and without coronary artery lesions (CALs). For evaluation of the relationships across laboratory indices, patients with a fever duration of 5 days or 6 days were used (n=204).
RESULTS
The mean fever duration was 6.6±2.3 days, and the proportions of patients with CALs was 19.3% (n=114). C-reactive proteins (CRPs) and neutrophil differential values were highest and hemoglobin, albumin, and lymphocyte differential values were lowest in the 6-day group. Patients with CALs had longer total fever duration, higher CRP and neutrophil differential values and lower hemoglobin and albumin values compared to patients without CALs. CRP, albumin, neutrophil differential, and hemoglobin values at the peak inflammation stage of KD showed positive or negative correlations each other.
CONCLUSION
The severity of systemic inflammation in KD was reflected in the laboratory values including CRP, neutrophil differential, albumin, and hemoglobin. Observing changes in these laboratory parameters by repeated examinations prior to the peak of inflammation in acute KD may aid in diagnosis of early-presenting KD patients.

Keyword

Kawasaki disease; C-reactive protein; Albumin; Hemoglobin; Coronary artery lesion

MeSH Terms

C-Reactive Protein
Coronary Vessels
Diagnosis
Early Diagnosis*
Fever
Humans
Inflammation
Lymphocytes
Mucocutaneous Lymph Node Syndrome*
Neutrophils
C-Reactive Protein