Gut Liver.
2016 Sep;10(5):719-725. 10.5009/gnl15262.
Long-Term Recurrence Rates of Peptic Ulcers without Helicobacter pylori
- Affiliations
-
- 1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. jikim@catholic.ac.kr
- 2Department of Internal Medicine, Digestive Disease Center and Research Institute, Soonchunhyang University College of Medicine, Bucheon, Korea.
- 3Division of Gastroenterology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.
- 5Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
- 6Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
- 7Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2412068
- DOI: http://doi.org/10.5009/gnl15262
Abstract
- BACKGROUND/AIMS
The purpose of this study is to investigate the recurrence rate of peptic ulcer disease (PUD) over a long follow-up period with PUD patients without Helicobacter pylori.
METHODS
We retrospectively reviewed patients diagnosed with PUD on endoscopy and divided them into two groups: a H. pylori-negative group (HP-negative group), and a group of patients with untreated H. pylori (HP noneradicated group). We compared the recurrence rates of PUD in these two groups and analyzed the factors that affected ulcer recurrence.
RESULTS
Total of nine hospitals in Korea participated, and a total of 1,761 patients were retrospectively reviewed. The HP-negative group included 553 patients, and the HP noneradicated group included 372 patients. The 5-year cumulative probabilities of PUD recurrence were 36.4% in the HP-negative group and 43.8% in the HP noneradicated group (p=0.113). The factors that were found to affect recurrence in the HP-negative group were elder, male, and comorbid chronic kidney disease.
CONCLUSIONS
The 5-year cumulative probability of PUD recurrence without H. pylori infection after a long-term follow-up was 36.4% and the factors that affected recurrence were elder, male, and comorbid chronic kidney disease.
MeSH Terms
-
Adult
Age Factors
Aged
Anti-Bacterial Agents/therapeutic use
Female
Follow-Up Studies
*Helicobacter Infections/complications/drug therapy/microbiology
*Helicobacter pylori
Humans
Male
Middle Aged
*Peptic Ulcer/drug therapy/etiology/microbiology
Recurrence
Renal Insufficiency, Chronic/complications/microbiology
Republic of Korea
Retrospective Studies
Risk Factors
Sex Factors
Time Factors
Anti-Bacterial Agents
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Helicobacter pylori-negative Peptic Ulcer
- Diagnosis and treatment of Helicobacter pylori infection in patients treated with non-steroidal anti-inflammatory drugs
- Prevention of Peptic Ulcer Associated with Aspirin and Antiplatelet Agent
- High Recurrence Rate of Idiopathic Peptic Ulcers in Long-Term Follow-up
- Helicobacter pylori Eradication in Drug-related Peptic Ulcer
