Korean J Intern Med.  2018 Mar;33(2):233-246. 10.3904/kjim.2018.031.

Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. mdohmd@snu.ac.kr

Abstract

Middle East Respiratory Syndrome coronavirus (MERS-CoV) was first isolated from a patient with severe pneumonia in 2012. The 2015 Korea outbreak of MERSCoV involved 186 cases, including 38 fatalities. A total of 83% of transmission events were due to five superspreaders, and 44% of the 186 MERS cases were the patients who had been exposed in nosocomial transmission at 16 hospitals. The epidemic lasted for 2 months and the government quarantined 16,993 individuals for 14 days to control the outbreak. This outbreak provides a unique opportunity to fill the gap in our knowledge of MERS-CoV infection. Therefore, in this paper, we review the literature on epidemiology, virology, clinical features, and prevention of MERS-CoV, which were acquired from the 2015 Korea outbreak of MERS-CoV.

Keyword

Coronavirus infections; Middle East respiratory syndrome coronavirus; Coronavirus; Korea; Disease outbreaks

MeSH Terms

Coronavirus
Coronavirus Infections*
Disease Outbreaks
Epidemiology
Humans
Korea
Middle East Respiratory Syndrome Coronavirus
Middle East*
Pneumonia
Republic of Korea*
Virology
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