J Korean Soc Echocardiogr.  1995 Jul;3(1):23-26. 10.4250/jkse.1995.3.1.23.

Recurrent Systemic Embolizetion Caused by Aortic Thrombus in Antiphospholipid Antibody syndrome: A Case Report

Affiliations
  • 1Department of Internal Medicine, Seoul National University, College of Medicine, Seoul, Korea.
  • 2Department of Internal Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.

Abstract

Antiphospholipid antibody syndrome is characterized by recurrent fetal loss, neurologic dysfunction, arterial and venous thrombosis, and systemic and pulmonary hypertension associated with antiphospholipid antibodies. We observed a large visible thrombus in the descending aorta leading to multiple systemic embolism in a patient with antiphospholipid antibody without other risk factors for thrombosis. We assume that this thombus is associated with antiphospholipid antibody syndrome.

Keyword

Antiphospholipid Antibody Syndrome; Aortic Thrombus; Systemic embolization

MeSH Terms

Antibodies, Antiphospholipid*
Antiphospholipid Syndrome*
Aorta, Thoracic
Embolism
Humans
Hypertension, Pulmonary
Neurologic Manifestations
Risk Factors
Thrombosis*
Venous Thrombosis
Antibodies, Antiphospholipid

Figure

  • Fig. 1. Transesophageal echocardiography shows large mobile mass in descending aorta. A) horizontal view B) longitudinal view Th: thrombus

  • Fig. 2. A) Multiple filling defect in left kidney suggesting renal infarction. B) CT angiography shows large pendulous mass in descending aorta.

  • Fig. 3. Follow-up transesophageal echocardiography' shows apparently decreased mass size.


Reference

References

1). Mitusch R, Stierle U, Tepe C, Kummer P, Kessler C, Seikhzadeh A. Systemic embolism in aortic arch atheromatosis. Eur Heart J. 15(10):1373–80. 1994.
Article
2). Aldrich HR, Girardi L, Bush HL, Dedevereux RB, Rosengart TK. Recurrent systemic embolization caused by aortic thrombi, Ann Thorac Surg. 57:466–8. 1994.
3). Sharifi M, Sorkln R. Lakier J, Chaitra S. Thoracic aortic thrombosis as a cause of bowel ischemia: A case report, Angiology. 45(11):973–7. 1994.
4). Josephson GD, Tiefenbrun J, Harvey J. Thrombosis of the descending thoracic aorta: A case report. Surgery. 114:598–600. 1993.
5). Machleder HI, Takiff H, Lois JF, Holburt E. Aortic mural thrombus: An occult source of arterial thromboembolism, J Vasc Surg. 4:473–8. 1986.
6). Tunick PA, Perez JC, Kronzon I. Protruding atheromas in the thoracic aorta and systemic embolization. Ann Intern Med. 115:423–7. 1991.
Article
7). Karalis DG, Chandrasekaran K, and Victor MF Ross JJ, Mintz GS. Recognition and embolic potential of intraaortic atherosclerotic debris. J Am Coll Cardiol. 17:73–8. 1991.
Article
8). Wasserinann A. Neissr A, Bruck C. Eine serodiagnostische reaktion bei syphilis. Dtsch Med Wochenschr. 32:745–46. 1906.
Article
9). Conley CL, Hartmann RC. A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J Clin Invest. 31:621–22. 1952.
10). Meyer O, Cyna L, Bourgeois P, Kahn MF, Ryckewaert A. Profile and cross reactivities of antiphospholipid antibodies in systemic lupus erythematosus and syphilis. Clin Rheumatol. 6:369–77. 1987.
11). Meyer O, Piette JC, Bourgeois P. Antiphospholipid antibodies: A disease marker in 25 patients with autoimmune antibody negative SLE. J Rheumatol. 14:502–06. 1987.
12). Manoussakis MN, Gharavi AE, Drosos AA, Kitridou RC, Moutsopoulous HM. Anticardiolipin antibodies in unselected autoimmune rheumatic disease patients. Clin Immunol Immunopathol. 44:297–307. 1987.
Article
13). McGee GS, Pearce WH, Sharma L, Green D, Yao JS. Antiphospholipid antibodies and arterial thrombosis: Case reports and a review of the literature. Arch Surg. 127:342–6. 1992.
14). Ordi RJ, Perez PP, Monasterio J. Clinical and therapeutic aspects associated to phospholipid binding antibodies. Haemostasis. 24(3):165–74. 1994.
Full Text Links
  • JKSE
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr