Korean J Dermatol.  1999 Apr;37(4):519-522.

A Case of Leukocytoclastic Vasculitis Associated with Antiphospholipid Antibody Syndorme

• Kim TH
• Choi EH
• Hwang SM
• Ahn SK

Abstract

The antiphospholipid antibody syndrome is an acquired multisystemic disorder characterized by persistent elevated antiphospholipid antibodies and/or hypercoagulation in veins or arteries, or both. The clinical manifestations of the antiphospholipid antibody syodrome are recurrent thrombosis, fetal loss, thrcenbocytopenia, and various cutaneous lesions. Skin lesions are the first sign of this syndrome in 41% of patients and systemic thrombosis develops in 40% of them. Livedo reticularis is the most common cutaneous finding of the antiphosphotipid antibody syndrome. Although vasculitis has not been frequently noted in antiphospholipid antibody syndrome, some vasculitis such as polyarteritis nodosa, giant cell arteritis, and other nonspecific vasculitides have been found in association with antiphospholipid antibody syndrome. We present a male patient with typical manifestations of leukocytoclastic vasculitis with deep vein thrombosis and positive antiphospholipid antibodies. It suggests that a case of antiphospholipid antibody syndorme was accompanied with cutaneous leukocytoclastic vasculitis.

Keyword

Antiphospholipid antibody syndrome; Leukocytoclastic vasculitis; Deep vein thrombosis

MeSH Terms

Antibodies, Antiphospholipid*
Antiphospholipid Syndrome
Arteries
Giant Cell Arteritis
Humans
Livedo Reticularis
Male
Polyarteritis Nodosa
Skin
Thrombosis
Vasculitis*
Vasculitis, Leukocytoclastic, Cutaneous
Veins
Venous Thrombosis
Antibodies, Antiphospholipid