Brain Tumor Res Treat.  2018 Apr;6(1):8-12. 10.14791/btrt.2018.6.e2.

Optic Nerve Sheath Meningioma: Preliminary Analysis of the Role of Radiation Therapy

• Jin J
• Joo JD
• Han JH
• Yang HK
• Hwang JM
• Kim YJ
• Kim IA
• Kim CY

• KMID: 2410232
• DOI: http://doi.org/10.14791/btrt.2018.6.e2

Abstract

BACKGROUND
The purpose of this study was to evaluate the treatment outcome of our optic nerve sheath meningioma (ONSM) case series in terms of preventing tumor growth and preserving vision in ONSM patients.
METHODS
Between July 2003 and March 2015, 1,398 patients with intracranial meningioma were diagnosed at Seoul National University Bundang Hospital. Among them, only 13 patients (0.93%) were diagnosed with ONSM and enrolled in the present study. Tumor volume changes of ONSM patients and their visual acuity were evaluated before and after treatments.
RESULTS
The median follow-up time was 50 months (range, 12-133 months). Visual acuity was evaluated in 12 of 13 patients, and visual acuity was found to be preserved in 9 of 12 patients (75%). Tumor volume was reduced in all patients. The tumor control rate was 100% in the present study. The difference in tumor volume between pretreatment and last follow-up was statistically significant (p=0.015).
CONCLUSION
Intensity-modulated radiotherapy (IMRT) and gamma knife radiosurgery (GKS) could maintain visual acuity and stabilize tumor volume in ONSM patients, suggesting that IMRT and GKS may be effective therapies for ONSM. However, which treatment is the more effective modality must be confirmed by prospective studies and longer-term follow-up.

Keyword

Optic nerve; Meningioma; Visual acuity; Tumor volume; Stereotactic radiosurgery

MeSH Terms

Follow-Up Studies
Humans
Meningioma*
Optic Nerve*
Prospective Studies
Radiosurgery
Radiotherapy, Intensity-Modulated
Seoul
Treatment Outcome
Tumor Burden
Visual Acuity

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