J Gynecol Oncol.
2018 May;29(3):e30. 10.3802/jgo.2018.29.e30.
Androgen receptor as a prognostic biomarker and therapeutic target in uterine leiomyosarcoma
- Affiliations
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- 1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. catgut1-0@hanmail.net
- 2Department of Obstetrics and Gynecology, Hallym University Sacred Heart Hospital, Anyang, Korea.
- 3Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- KMID: 2409934
- DOI: http://doi.org/10.3802/jgo.2018.29.e30
Abstract
OBJECTIVE
To investigate the expression of androgen receptor (AR) and its correlation with disease status and survival outcome in uterine leiomyosarcoma with other hormone receptors.
METHODS
The medical records and paraffin blocks of 42 patients were reviewed. The immunohistochemical expression of AR, estrogen receptor (ER), progesterone receptor (PR), gonadotropin releasing hormone (GnRH), and cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1) were assessed using tissue microarray.
RESULTS
In total, AR expression was observed in 11 patients (26.2%). International Federation of Gynecology and Obstetrics (FIGO) stage and AR were independent factors for disease-free survival (DFS) in multivariate regression analysis (odds ratio [OR]=5.8; 95% confidence interval [CI]=1.2-28.4 and OR=0.2; 95% CI=0.05-0.90; p=0.029 and 0.032, respectively). There were no deaths in the AR expression group, whereas the 5-year overall survival (OS) was 54.8% in the no expression group (p=0.014). Co-expression of ER and/or PR with AR was associated with significantly better 5-year DFS and OS than those with negative AR (72.7% vs. 28.6% and 100% vs. 64.3%; p=0.020 and 0.036, respectively). AR may be an independent prognostic marker regardless of ER/PR.
CONCLUSION
AR can be a potential prognostic biomarker in uterine leiomyosarcoma.
MeSH Terms
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Cytochrome P-450 Enzyme System
Disease-Free Survival
Estrogens
Gonadotropin-Releasing Hormone
Gynecology
Humans
Immunohistochemistry
Leiomyosarcoma*
Medical Records
Obstetrics
Paraffin
Receptors, Androgen*
Receptors, Progesterone
Cytochrome P-450 Enzyme System
Estrogens
Gonadotropin-Releasing Hormone
Paraffin
Receptors, Androgen
Receptors, Progesterone
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