Nat Prod Sci.  2015 Mar;21(1):1-5. 10.0000/nps.2015.21.1.1.

Bioactive Constituents from the Leaves of Zanthoxylum schinifolium

• Jeong SY
• Nguyen PH
• Zhao BT
• Min BS
• Ma ES
• Woo MH

• KMID: 2409591
• DOI: http://doi.org/10.0000/nps.2015.21.1.1

Abstract

Activity-guided separation of the methylene chloride-soluble fraction of the leaves of Zanthoxylum schinifolium, resulted in the isolation of four coumarinoids (1 - 4), two triterpenoids (5, 6) and three fatty acid derivatives (7 - 9) as active principles. Their chemical structures were identified as collinin (1), 8-methoxyanisocoumarin (2), 7-(6'R-hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)-coumarin (3), (E)-4-methly-6-(coumarin-7'-yloxy) hex-4-enal (4), lupeol (5), epi-lupeol (6), phytol (7), hexadec-3-enoic acid (8) and palmitic acid (9), on the basis of spectroscopic (1D, 2D and MS) data analyses and comparing with the data published in the literatures. Compounds 1 and 7 showed potent cytotoxicity against Jurkat T cells with IC50 values of 45.58 and 47.51 microM, respectively. The others showed moderate activity with IC50 values ranging around 80.58 to 85.83 microM, while the positive control, auraptene, possessed an IC50 value of 55.36 microM.

Keyword

Zanthoxylum schinifolium; Rutaceae; Cytotoxicity; Collinin; Phytol

MeSH Terms

Inhibitory Concentration 50
Palmitic Acid
Phytol
Rutaceae
Statistics as Topic
T-Lymphocytes
Zanthoxylum*
Palmitic Acid
Phytol