J Korean Med Sci.  2018 Apr;33(17):e124. 10.3346/jkms.2018.33.e124.

Association of Adiponectin 45T/G Polymorphism with Diabetic Cardiovascular Complications in Korean Type 2 Diabetes

• Ji MJ
• Ku EJ
• Oh TK
• Jeon HJ

• KMID: 2409201
• DOI: http://doi.org/10.3346/jkms.2018.33.e124

Abstract

BACKGROUND
Adiponectin is an adipokine that regulates lipid and glucose metabolism and has been shown to have anti-inflammatory and anti-atherogenic effects. It also plays an important role in the development of cardiovascular disease (CVD).
METHODS
This study evaluated the association between adiponectin 45T/G polymorphism and cardiovascular complication in type 2 diabetes in Koreans.
RESULTS
The present study included 758 patients with type 2 diabetes. The distribution of the adiponectin 45T/G polymorphism was 3.56% (n = 27) for GG, 42.35% (n = 321) for TG, and 54.09% (n = 410) for TT in patients with type 2 diabetes. The prevalence of CVD was significantly higher in subjects with the GG + TG genotype compared to those with the TT genotype (17.5% vs. 9.8%, P = 0.002). The G allele was associated with a higher risk of CVD (P = 0.002).
CONCLUSION
Our findings suggest that the adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes.

Keyword

Type 2 Diabetes; Adiponectin; Cardiovascular Complication; Polymorphism

MeSH Terms

Adipokines
Adiponectin*
Alleles
Cardiovascular Diseases
Genotype
Glucose
Humans
Metabolism
Prevalence
Adipokines
Adiponectin
Glucose