J Korean Soc Echocardiogr.
2004 Dec;12(2):78-82.
Short-Term Effect of High Dose of Vitamin C on Coronary Flow Velocity and Coronary Flow Reserve in Healthy Young Non-Smoker Men
- Affiliations
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- 1Department of Internal Medicine, Wonkwang University School of Medicine, The Institute of Medical Sciences, Iksan, Korea. jjwcar@wonkwang.ac.kr
Abstract
- BACKGROUND AND OBJECTIVES
Vitamin C, water-soluble antioxidant, has been reported to restore coronary microcirculatory responsiveness and impaired coronary flow reserve in smokers. However, the effect of high dose of vitamin C on coronary circulation is unclear in nonsmokers.
METHODS
We used transthoracic echocardiography to measure the coronary flow reserve, an integrated measure of coronary flow in 20 male healthy nonsmokers (26+/-3 years) before and after administration of the high dose of vitamin C.
RESULTS
The coronary peak diastolic velocity was increased by 14.8% after administration of antioxidant vitamin C, whereas the coronary flow reserve did not changed.
CONCLUSION
High dose of vitamin C acutely increases the coronary flow velocity without restoration of coronary flow reserve in male healthy nonsmokers.
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