J Pathol Transl Med.  2018 Mar;52(2):133-135. 10.4132/jptm.2016.12.21.

Denosumab-Treated Giant Cell Tumor of the Bone Mimicking Low-Grade Central Osteosarcoma

• Wu CC
• Hsieh PP

• KMID: 2408516
• DOI: http://doi.org/10.4132/jptm.2016.12.21

Abstract

No abstract available.

MeSH Terms

Giant Cell Tumors*
Giant Cells*
Osteosarcoma*

Figure

• 

  Fig. 1. (A) The typical picture of giant cell tumor before treatment shows “giant” osteoclasts with >20 and sometimes >50 nuclei. (B) Magnetic resonance imaging reveals an expansile, eccentric osteolytic bone tumor around epiphysis and metaphysis of left distal femur. (C, D) Compared with ordinary giant cell tumor, this case exhibits reduced number and size of osteoclast-like giant cells and also abundant new bone deposition, mimicking low-grade central osteosarcoma. (E) The immunohistochemical result shows negative for MDM2. (F) H3F3A hotspot mutation (G34W) is detected.

Reference

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