Ann Rehabil Med.  2014 Apr;38(2):256-262.

Impact of Exercise-Based Cardiac Rehabilitation on De Novo Coronary Lesion in Patients With Drug Eluting Stent

• Choi HE
• Lee BJ
• Kim C

Abstract

OBJECTIVE
To compare the rate of progression of de novo lesion between the cardiac rehabilitation (CR) and control groups.
METHODS
This is a retrospective observational study. Patients who received drug-eluting stent (DES) due to acute coronary syndrome were included as subjects. The CR group received eight weeks of early CR program, and sustained a self-exercise program in the homes. The control group was instructed to exercise independently. Nine months after the first insertion of DES, we implemented follow-up coronary angiography, and compared the rate of progression of de novo lesion by quantitative angiographic measurement between the two groups.
RESULTS
A total of 81 patients were recruited as subjects to CR group (n=32) or control group (n=49). At nine months, late luminal loss was 0.04+/-0.23 mm in the CR group and 0.00+/-0.31 mm in the control group (p=0.54, observed power=0.10). Late loss was -0.90%+/-9.53% in the CR group and 0.80%+/-11.15% in the control group (p=0.58, observed power=0.05). No target lesion revascularization procedures were needed in the CR group, while two in the control group (p=0.25). In the CR group, mean VO2max was significantly improved from 24.36+/-5.00 to 27.68+/-5.24 mL/kg/min (p<0.001).
CONCLUSION
We could not observe a statistically significant difference in the progression rate of de novo lesion between the CR and control groups. Thus the current amount of nine months exercise-based CR program does not seem to have a distinct impact on the retardation of de novo coronary lesion in patients who received percutaneous coronary intervention with DES.

Keyword

Coronary stenosis; Drug-eluting stents; Exercise; Rehabilitation

MeSH Terms

Acute Coronary Syndrome
Coronary Angiography
Coronary Stenosis
Drug-Eluting Stents
Follow-Up Studies
Humans
Observational Study
Percutaneous Coronary Intervention
Phenobarbital
Rehabilitation*
Retrospective Studies
Stents*
Phenobarbital

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