Nucl Med Mol Imaging.
2018 Feb;52(1):5-15. 10.1007/s13139-017-0493-6.
Current Methods to Define Metabolic Tumor Volume in Positron Emission Tomography: Which One is Better?
- Affiliations
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- 1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. scho@uwhealth.org
- 2Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
- 3Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- 4University ofWisconsin Carbone Cancer Center,Madison, WI, USA.
- KMID: 2407296
- DOI: http://doi.org/10.1007/s13139-017-0493-6
Abstract
- Numerous methods to segment tumors using ¹â¸F-fluorodeoxyglucose positron emission tomography (FDG PET) have been introduced. Metabolic tumor volume (MTV) refers to the metabolically active volume of the tumor segmented using FDG PET, and has been shown to be useful in predicting patient outcome and in assessing treatment response. Also, tumor segmentation using FDG PET has useful applications in radiotherapy treatment planning. Despite extensive research on MTV showing promising results, MTV is not used in standard clinical practice yet, mainly because there is no consensus on the optimal method to segment tumors in FDG PET images. In this review, we discuss currently available methods to measure MTV using FDG PET, and assess the advantages and disadvantages of the methods.
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