Vasc Spec Int.
2017 Dec;33(4):146-155. 10.5758/vsi.2017.33.4.146.
Neuropsychological Outcome One Year after Carotid Revascularization: A before-and-after Study
- Affiliations
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- 1Servei de Neurologia, Hospital Universitari Mútua Terrassa, Barcelona, Spain. lauracasass@gmail.com
- 2Departament de Psiquiatria i de Medicina Legal, Universitat Autònoma de Barcelona, Barcelona, Spain.
- 3Neuropsychological Unit, Hospital of Terrassa-Consorci Sanitari de Terrassa, Barcelona, Spain.
- 4Servei de Medicina Intensiva, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
- 5Unitat d’Urgències, Hospital Plató, Barcelona, Spain.
- 6Servei de Cirurgia Vascular, Hospital Universitari Mútua Terrassa, Barcelona, Spain.
- KMID: 2405678
- DOI: http://doi.org/10.5758/vsi.2017.33.4.146
Abstract
- PURPOSE
The aim of our study was to determine the clinical profile of patients considered cognitive "˜responders' to surgery in order to establish clinical variables associated with a favorable cognitive performance.
MATERIALS AND METHODS
A total of 70 patients were included in the study. A well-validated, comprehensive standardized neurocognitive battery of tests of about 2 hours was administered. Patients were examined twice, 1-week before surgery and 1-year postoperatively. The criterion to be included in the "˜responder' group was the following: to obtain a positive difference between post-revascularization and pre-revascularization neuropsychological assessment ≥1 standard deviation in ≥2 tests.
RESULTS
Twenty-seven patients (38.6%) were cognitive responders to treatment. In bivariate analysis between responders and non-responders, presence of atrophy (P=0.003), small vessels (P=0.577), symptoms (P=0.046), and age (P=0.030) were the factors statistically significant. When comparing cognitive performance before and after carotid revascularization, significant differences were observed in semantic fluency with a lower performance after 12 months (P=0.004, d=0.29), and in the Language index (Repeatable Battery for the Assessment of Neuropsychological Status) (P=0.005, d=0.34).
CONCLUSION
Patients without neurological symptoms, of a younger age and without atrophy and white matter small vessel lesions are better cognitive responders 1-year after carotid revascularization.
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