Soonchunhyang Med Sci.  2017 Dec;23(2):155-158. 10.0000/sms.2017.23.2.155.

Long-Term Functional Outcome of Peripheral Neuropathy in Microscopic Polyangiitis with Poor Prognostic Factors: 3-Year Clinical Follow-up

• Oh HG
• Gil HW
• Lee JH

• KMID: 2404866
• DOI: http://doi.org/10.0000/sms.2017.23.2.155

Abstract

Microscopic polyangiitis (MPA) is a systemic small vessel vasculitis with few or no immune deposits and no granulomatous inflammation. Peripheral neuropathy occurs in approximately 20%-30% of patients with MPA. We report a case of a 66-year-old woman who presented with paresthesia and motor weakness of the extremities and rapidly progressive glomerulonephritis. She was later diagnosed with MPA based on the findings of positive perinuclear antineutrophil cytoplasmic antibody along with findings on kidney biopsy. Nerve conduction study showed symmetric sensorimotor polyneuropathy. We followed the patient for 3 years, and she showed good functional outcome after immune-modulating therapy although Five-Factor Score more than 2 at diagnosis.

Keyword

Vasculitis; Neuropathy; Outcome

MeSH Terms

Aged
Antibodies, Antineutrophil Cytoplasmic
Biopsy
Diagnosis
Extremities
Female
Follow-Up Studies*
Glomerulonephritis
Humans
Inflammation
Kidney
Microscopic Polyangiitis*
Neural Conduction
Paresthesia
Peripheral Nervous System Diseases*
Polyneuropathies
Vasculitis
Antibodies, Antineutrophil Cytoplasmic