Clin Hypertens.  2017 ;23(1):20. 10.1186/s40885-017-0077-x.

Identifying treatment response to antihypertensives in patients with obesity-related hypertension

• Schrover I
• Dorresteijn JAN
• Smits JE
• Danser AH
• Visseren F
• Spiering W

• KMID: 2404105
• DOI: http://doi.org/10.1186/s40885-017-0077-x

Abstract

BACKGROUND
In patients with obesity-related hypertension (ORH), reaction to antihypertensive medication is likely influenced by patientcharacteristics.
METHODS
Effects of aliskiren, moxonidine and hydrochlorothiazide on 24-h blood pressure (BP) were compared to placebo. Linear mixed effect models were used to analyze the effect of patient characteristics on BP levels and treatment response.
RESULTS
Systolic BP response to aliskiren was higher in patients with a BMI >"‰30.7 kg/m2 compared to patients with a BMI â‰¤"‰30.7 kg/m2 (−21 mmHg versus -4 mmHg). In patients with a hsCRP >"‰1.8 mg/L the systolic BP response to aliskiren was higher than in patients with a low hsCRP (−15 mmHg versus −7 mmHg). Hydrochlorothiazide (HCTZ) treatment effect on systolic BP was −13 mmHg when heart rate >"‰71 beats/min compared to -3 mmHg when heart rate was ≤"‰71 beats/min.
CONCLUSION
In patients with ORH, BP response to aliskiren is positively related to BMI and hsCRP. Systolic BP response to HCTZ is positively related to heart rate and negatively to renin levels. TRIAL REGISTRATION: NCT01138423. Registered June 4th, 2010.

Keyword

Hypertension; Obesity; Treatment; Interaction

MeSH Terms

Antihypertensive Agents*
Blood Pressure
Heart
Heart Rate
Humans
Hydrochlorothiazide
Hypertension*
Obesity
Renin
Antihypertensive Agents
Hydrochlorothiazide
Renin