Clin Hypertens.  2017 ;23(1):2. 10.1186/s40885-016-0058-5.

Association between central blood pressure, arterial stiffness, and mild cognitive impairment

• Suleman R
• Padwal R
• Hamilton P
• Senthilselvan A
• Alagiakrishnan K

• KMID: 2404087
• DOI: http://doi.org/10.1186/s40885-016-0058-5

Abstract

BACKGROUND
To determine the relationship between central blood pressure (CBP) indices and mild cognitive impairment (MCI) in adults over the age of 50.
METHODS
A cross-sectional study conducted using a non-invasive SphygmoCor XCEL device. CBP indices and brachial blood pressure were measured in 50 inpatients and outpatients. MCI was assessed using the Montreal Cognitive Assessment (MoCA) instrument and by the European Consortium Criteria (ECC).
RESULTS
Seventy-six percent of subjects had hypertension, and 52% were diagnosed as having MCI using the ECC. No significant association was found between any of the measured blood pressure variables and global cognition. A significant relationship was observed between augmentation index (AI) and abnormal clock-drawing (p = 0.04) and language (p = 0.02), and between pulse pressure amplification (PPA) and language (p = 0.03).
CONCLUSION
CBP indices like AI and PPA, which are markers of vascular stiffness, are associated with poor executive function and language cognitive domain deficits.

Keyword

Blood pressure; Augmentation pressure; Augmentation index; Arterial stiffness; Elderly; Cognitive impairment

MeSH Terms

Adult
Aged
Arterial Pressure*
Blood Pressure*
Cognition
Cognition Disorders
Cross-Sectional Studies
Executive Function
Humans
Hypertension
Inpatients
Mild Cognitive Impairment*
Outpatients
Vascular Stiffness